tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

Base Information

Chemical Name:tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate
CAS No.:1415757-43-5
Molecular Formula:C₂₅H₂₆ClFN₄O₄
Molecular Weight:500.957
Hs Code.:

Synonyms:tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

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Chemical Property of tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

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Technology Process of tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

There total 8 articles about tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 138907-81-0
1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

: 1400997-62-7
tert-butyl (RS)-2-(4-amino-3-chlorophenyl)morpholine-4-carboxylate

: 1415757-43-5
tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

Guidance literature:: 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

tert-butyl (RS)-2-(4-amino-3-chlorophenyl)morpholine-4-carboxylate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 21900-32-3
4-bromo-3-chlorobenzoyl chloride

: 1415757-43-5
tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethyl ether; acetonitrile; tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 0.5 h / 0 - 20 °C

2.1: ethanol; sodium tetrahydroborate / 1.58 h / 5 - 20 °C

2.2: 4 h / 50 °C

3.1: tetrahydrofuran / 7 h / 20 °C

4.1: tetrahydrofuran / 0 - 20 °C

5.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 - 20 °C

5.2: 0.5 h / 0 - 20 °C

6.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 90 °C / Inert atmosphere

7.1: hydroxylamine hydrochloride; sodium acetate / methanol / 21 h / 20 - 60 °C

8.1: oxalyl dichloride / N,N-dimethyl-formamide / 1,2-dichloro-ethane / 1 h / 20 °C

8.2: 2 h / 20 °C

With sodium tetrahydroborate; oxalyl dichloride; ethanol; hydroxylamine hydrochloride; sodium acetate; methanesulfonyl chloride; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; 1,2-dichloro-ethane; toluene; acetonitrile;

Reference yield:

: 1400997-57-0
(RS)-2-(4-bromo-3-chloro-phenyl)-oxirane

: 1415757-43-5
tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 7 h / 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 0.5 h / 0 - 20 °C

4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 90 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride; sodium acetate / methanol / 21 h / 20 - 60 °C

6.1: oxalyl dichloride / N,N-dimethyl-formamide / 1,2-dichloro-ethane / 1 h / 20 °C

6.2: 2 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; sodium acetate; methanesulfonyl chloride; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; toluene;