3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-<<4-(1H-tetrazol-5-yl)butyl>oxy>phenyl>propanoic acid ethyl ester

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Chemical Name:3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-<<4-(1H-tetrazol-5-yl)butyl>oxy>phenyl>propanoic acid ethyl ester
CAS No.:152608-91-8
Molecular Formula:C₄₀H₄₅FN₄O₆
Molecular Weight:696.819
Hs Code.:

Synonyms:3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-<<4-(1H-tetrazol-5-yl)butyl>oxy>phenyl>propanoic acid ethyl ester

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Chemical Property of 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-<<4-(1H-tetrazol-5-yl)butyl>oxy>phenyl>propanoic acid ethyl ester

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Technology Process of 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-<<4-(1H-tetrazol-5-yl)butyl>oxy>phenyl>propanoic acid ethyl ester

There total 12 articles about 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-<<4-(1H-tetrazol-5-yl)butyl>oxy>phenyl>propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 152608-89-4
ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate

: 152608-91-8
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-<<4-(1H-tetrazol-5-yl)butyl>oxy>phenyl>propanoic acid ethyl ester

Guidance literature:: With sodium azide; triethylamine hydrochloride; In N,N-dimethyl-formamide; at 125 ℃; for 22h;
DOI:10.1021/jm00022a006

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 152608-91-8
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-<<4-(1H-tetrazol-5-yl)butyl>oxy>phenyl>propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 52 percent / K₂CO₃, KI / dimethylformamide / 24 h / 90 °C

6: 71 percent / NaN₃, Et₃N*HCl / dimethylformamide / 22 h / 125 °C

With triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; triethylamine hydrochloride; sodium carbonate; potassium carbonate; trifluoroacetic acid; potassium iodide; In tetrachloromethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; butanone; benzene;
DOI:10.1021/jm00022a006

Reference yield:

: 5414-21-1
5-bromopentan-1-nitrile

: 152608-91-8
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-<<4-(1H-tetrazol-5-yl)butyl>oxy>phenyl>propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

2: pivalic acid / toluene / 16 h / Heating

3: aq. HCl / tetrahydrofuran / 1 h / Ambient temperature

4: 52 percent / K₂CO₃, KI / dimethylformamide / 24 h / 90 °C

5: 71 percent / NaN₃, Et₃N*HCl / dimethylformamide / 22 h / 125 °C

With hydrogenchloride; sodium azide; triethylamine hydrochloride; potassium carbonate; potassium iodide; Trimethylacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00022a006