ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate

Base Information

Chemical Name:ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate
CAS No.:127132-19-8
Molecular Formula:C₂₄H₄₇NO₅Si
Molecular Weight:457.726
Hs Code.:

Synonyms:ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate

Suppliers and Price of ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate

There total 7 articles about ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 141-52-6
sodium ethanolate

: 127132-18-7
(4S,5S)-N-(tert-butoxycarbonyl)-5-(cyclohexylmethyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidin-2-one

: 127132-19-8
ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate

Guidance literature:: In ethanol; Ambient temperature;
DOI:10.1021/jo00299a045

Reference yield:

: (S)-3-Hydroxy-N-((R)-1-phenyl-ethyl)-pent-4-enimidothioic acid methyl ester

: 127132-19-8
ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: I₂ / tetrahydrofuran / 48 h / 5 °C

2: 1) CuBr*SMe₂ / 1) THF, -35 deg C, 5 min, 2) -30 deg C, 6 h

3: 98 percent / imidazole, DMAP / dimethylformamide / 36 h / Ambient temperature

4: Na, NH₃ / tetrahydrofuran / 1 h / Heating

5: DMAP / acetonitrile / 4 h / Ambient temperature

6: 50 percent / ethanol / Ambient temperature

With 1H-imidazole; dmap; copper(I) bromide dimethylsulfide complex; ammonia; iodine; sodium; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00299a045

Reference yield:

: (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-cyclohexylmethyl-pyrrolidin-2-one

: 127132-19-8
ethyl (3S,4S)-4-<(tert-butoxycarbonyl)amino>-3-<(tert-butyldimethylsilyl)oxy>-5-cyclohexylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP / acetonitrile / 4 h / Ambient temperature

2: 50 percent / ethanol / Ambient temperature

With dmap; In ethanol; acetonitrile;
DOI:10.1021/jo00299a045