(S)-benzyl 2-(8-methyl-1-(4-(4-propylpyridin-2-ylcarbamoyl)phenyl)imidazo[1 ,5-a]pyrazin-3-yl)piperidine-1-carboxylate

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Chemical Name:(S)-benzyl 2-(8-methyl-1-(4-(4-propylpyridin-2-ylcarbamoyl)phenyl)imidazo[1 ,5-a]pyrazin-3-yl)piperidine-1-carboxylate
CAS No.:1418307-28-4
Molecular Formula:C₃₅H₃₆N₆O₃
Molecular Weight:588.709
Hs Code.:

Synonyms:(S)-benzyl 2-(8-methyl-1-(4-(4-propylpyridin-2-ylcarbamoyl)phenyl)imidazo[1 ,5-a]pyrazin-3-yl)piperidine-1-carboxylate

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Chemical Property of (S)-benzyl 2-(8-methyl-1-(4-(4-propylpyridin-2-ylcarbamoyl)phenyl)imidazo[1 ,5-a]pyrazin-3-yl)piperidine-1-carboxylate

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Technology Process of (S)-benzyl 2-(8-methyl-1-(4-(4-propylpyridin-2-ylcarbamoyl)phenyl)imidazo[1 ,5-a]pyrazin-3-yl)piperidine-1-carboxylate

There total 5 articles about (S)-benzyl 2-(8-methyl-1-(4-(4-propylpyridin-2-ylcarbamoyl)phenyl)imidazo[1 ,5-a]pyrazin-3-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1418307-27-3
N-(4-propylpyridin-2-yl)-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)benzamide

: 1418307-26-2
(S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate

: 1418307-28-4
(S)-benzyl 2-(8-methyl-1-(4-(4-propylpyridin-2-ylcarbamoyl)phenyl)imidazo[1 ,5-a]pyrazin-3-yl)piperidine-1-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 140 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 61702-15-6
4-propylpyridin-2-amine

: 1418307-28-4
(S)-benzyl 2-(8-methyl-1-(4-(4-propylpyridin-2-ylcarbamoyl)phenyl)imidazo[1 ,5-a]pyrazin-3-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 380499-68-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid chloride

: 1418307-28-4
(S)-benzyl 2-(8-methyl-1-(4-(4-propylpyridin-2-ylcarbamoyl)phenyl)imidazo[1 ,5-a]pyrazin-3-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water;