3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Base Information

Chemical Name:3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside
CAS No.:328312-06-7
Molecular Formula:C₄₅H₅₂N₆O₉Si
Molecular Weight:849.028
Hs Code.:

Synonyms:3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Suppliers and Price of 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

There total 5 articles about 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 122-04-3
4-nitro-benzoyl chloride

: 328311-88-2
3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[4-guanidine-5-methylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

: 328312-06-7
3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Guidance literature:: In pyridine; for 2h;
DOI:10.1016/S0040-4020(00)00991-1

Reference yield:

: 80971-33-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine

: 328312-06-7
3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Guidance literature:: Multi-step reaction with 3 steps

1.1: POCl₃; Et₃N / acetonitrile / 0.5 h / 0 °C

1.2: acetonitrile / 0 - 20 °C

2.1: 70 percent / K₂CO₃ / dimethylformamide / 3 h / 100 °C

3.1: 75 percent / pyridine / 2 h

With potassium carbonate; triethylamine; trichlorophosphate; In pyridine; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(00)00991-1

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 328312-06-7
3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-(4-nitrobenzoyl)guanidinepyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / imidazole / pyridine / 6 h

2.1: POCl₃; Et₃N / acetonitrile / 0.5 h / 0 °C

2.2: acetonitrile / 0 - 20 °C

3.1: 70 percent / K₂CO₃ / dimethylformamide / 3 h / 100 °C

4.1: 75 percent / pyridine / 2 h

With 1H-imidazole; potassium carbonate; triethylamine; trichlorophosphate; In pyridine; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(00)00991-1