5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Base Information

Chemical Name:5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one
CAS No.:40018-02-8
Molecular Formula:C₁₄H₁₀F₂N₂OS
Molecular Weight:292.309
Hs Code.:

5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-<i>e</i>][1,4]diazepin-2-one

Synonyms:5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Chemical Property of 5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Technology Process of 5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

There total 11 articles about 5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 40017-81-0
5-(2,6-difluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

: 74-88-4
methyl iodide

: 40018-02-8
5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: With sodium methylate; In methanol; N,N-dimethyl-formamide; for 2h;
DOI:10.1002/ardp.19803130704

Reference yield:

: 56159-89-8
2-bromo-1-(2,6-difluorophenyl)ethanone

: 40018-02-8
5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / aq. ethanol / 1.5 h

2: 56 percent / Et₃N / dimethylformamide / 20 h / 50 °C

3: K₂CO₃ / dioxane / 2 h / Ambient temperature

4: NaI / acetone / 1 h / Heating

5: 52 percent / NH₃ / 5 h

6: 42 percent / isobutyric acid / 0.25 h / Heating

7: 77 percent / CH₃ONa / dimethylformamide; methanol / 2 h

With ammonia; sodium methylate; potassium carbonate; triethylamine; isobutyric Acid; sodium iodide; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1002/ardp.19803130704

Reference yield:

: 40017-77-4
2-Amino-3-(2,6-difluorbenzoyl)-thiophen

: 40018-02-8
5-(2,6-difluoro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dioxane / 2 h / Ambient temperature

2: NaI / acetone / 1 h / Heating

3: 52 percent / NH₃ / 5 h

4: 42 percent / isobutyric acid / 0.25 h / Heating

5: 77 percent / CH₃ONa / dimethylformamide; methanol / 2 h

With ammonia; sodium methylate; potassium carbonate; isobutyric Acid; sodium iodide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1002/ardp.19803130704