6-Chloro-3-ethoxycarbonyl-2-methyl-4-phenylquinoline

Base Information

• Chemical Name: 6-Chloro-3-ethoxycarbonyl-2-methyl-4-phenylquinoline
• CAS No.: 22609-01-4
• Molecular Formula: C19H16 Cl N O2
• Molecular Weight: 325.795
• Hs Code.: 2933499090
• Mol file: 22609-01-4.mol

Synonyms:6-Chloro-3-ethoxycarbonyl-2-methyl-4-phenylquinoline

Chemical Property of 6-Chloro-3-ethoxycarbonyl-2-methyl-4-phenylquinoline

Chemical Property:

• Melting Point: 108 °C
• Boiling Point: 442.0±45.0 °C(Predicted)
• PKA: 3.35±0.50(Predicted)
• PSA: 39.19000
• Density: 1.230±0.06 g/cm3(Predicted)
• LogP: 5.04030

Purity/Quality:

97% ^*data from raw suppliers

ETHYL 6-CHLORO-2-METHYL-4-PHENYLQUINOLINE-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-3-ethoxycarbonyl-2-methyl-4-phenylquinoline

There total 6 articles about 6-Chloro-3-ethoxycarbonyl-2-methyl-4-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl acetoacetate (141-97-9) + 5-chloro-2-aminobenzophenone (719-59-5) → ethyl 6-chloro-2-methyl-4-phenylquinoline-3-carboxylate (22609-01-4)

Guidance literature:

With magnesium(II) perchlorate; In ethanol; at 60 ℃; for 18h;

DOI:10.1055/s-2005-917111

Reference yield: 89.0%

5-chloro-2-aminobenzophenone (719-59-5) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → ethyl 6-chloro-2-methyl-4-phenylquinoline-3-carboxylate (22609-01-4)

Guidance literature:

With sodium salt of sulfated chitosan; In ethanol; at 50 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2013.07.165

Reference yield: 88.0%

Ethyl 2-butynoate (4341-76-8) + 5-chloro-2-aminobenzophenone (719-59-5) → ethyl 6-chloro-2-methyl-4-phenylquinoline-3-carboxylate (22609-01-4)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In neat (no solvent); at 110 ℃; for 3h;

DOI:10.1039/c3ra45576a

upstream raw materials:

ethyl acetoacetate

5-chloro-2-aminobenzophenone

Ethyl 2-oxobutanoate

(2-amino-5-chlorophenyl)(phenyl)methanol