N-{2-[N'-(5-o-Tolyl-[1,3,4]thiadiazol-2-yl)-guanidino]-ethyl}-acetamide

Base Information

• Chemical Name: N-{2-[N'-(5-o-Tolyl-[1,3,4]thiadiazol-2-yl)-guanidino]-ethyl}-acetamide
• CAS No.: 113112-83-7
• Molecular Formula: C₁₄H₁₈N₆OS
• Molecular Weight: 318.403

Synonyms:N-{2-[N'-(5-o-Tolyl-[1,3,4]thiadiazol-2-yl)-guanidino]-ethyl}-acetamide

Chemical Property of N-{2-[N'-(5-o-Tolyl-[1,3,4]thiadiazol-2-yl)-guanidino]-ethyl}-acetamide

Chemical Property:

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Technology Process of N-{2-[N'-(5-o-Tolyl-[1,3,4]thiadiazol-2-yl)-guanidino]-ethyl}-acetamide

There total 2 articles about N-{2-[N'-(5-o-Tolyl-[1,3,4]thiadiazol-2-yl)-guanidino]-ethyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

monoacetylaminoethylamine (1001-53-2) + 5-o-Tolyl-[1,3,4]thiadiazol-2-yl-cyanamide (113113-23-8) → N-{2-[N'-(5-o-Tolyl-[1,3,4]thiadiazol-2-yl)-guanidino]-ethyl}-acetamide (113112-83-7)

Guidance literature:

In butan-1-ol; Heating;

DOI:10.1021/jm00400a004

Reference yield:

2-chloro-5-(2-methylphenyl)-1,3,4-thiadiazole (40642-55-5) → N-{2-[N'-(5-o-Tolyl-[1,3,4]thiadiazol-2-yl)-guanidino]-ethyl}-acetamide (113112-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium hydride / 1.) DMF, room temperature, 30 min, 2.) DMF, 100 deg C , 1.5 h

2: 25 percent / butan-1-ol / Heating

With sodium hydride; In butan-1-ol;

DOI:10.1021/jm00400a004

Reference yield: 34.0%

N-{2-[N'-(5-o-Tolyl-[1,3,4]thiadiazol-2-yl)-guanidino]-ethyl}-acetamide (113112-83-7) → 1-(2-aminoethyl)-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride (113113-17-0)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 16h;

DOI:10.1021/jm00400a004

upstream raw materials:

monoacetylaminoethylamine

5-o-Tolyl-[1,3,4]thiadiazol-2-yl-cyanamide

2-chloro-5-(2-methylphenyl)-1,3,4-thiadiazole

Downstream raw materials:

1-(2-aminoethyl)-2-<5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl>guanidine dihydrochloride

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