4-(benzyloxy)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-fluoro-1-methyl-1H-indole

Base Information

Chemical Name:4-(benzyloxy)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-fluoro-1-methyl-1H-indole
CAS No.:1265218-61-8
Molecular Formula:C₂₄H₃₂FNO₂Si
Molecular Weight:413.607
Hs Code.:

Synonyms:4-(benzyloxy)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-fluoro-1-methyl-1H-indole

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Chemical Property of 4-(benzyloxy)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-fluoro-1-methyl-1H-indole

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Technology Process of 4-(benzyloxy)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-fluoro-1-methyl-1H-indole

There total 6 articles about 4-(benzyloxy)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-fluoro-1-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₀FNO₂Si

: 74-88-4
methyl iodide

: 1265218-61-8
4-(benzyloxy)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-fluoro-1-methyl-1H-indole

Guidance literature:: C₂₃H₃₀FNO₂Si; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

methyl iodide; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1265218-61-8
4-(benzyloxy)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-fluoro-1-methyl-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

2.2: 1 h

With 1H-imidazole; sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

: 1181566-76-6
1-bromo-5-fluoro-2-nitro-4-[(phenylmethyl)oxy]benzene

: 1265218-61-8
4-(benzyloxy)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-fluoro-1-methyl-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / -40 - 40 °C

2.1: diethyl ether / 0 - 20 °C

2.2: -20 °C

3.1: lithium aluminium tetrahydride / 1,4-dioxane / 1 h / Reflux

3.2: 0.33 h

4.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

5.2: 1 h

With 1H-imidazole; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;