toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester

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Chemical Name:toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester
CAS No.:286441-94-9
Molecular Formula:C₂₂H₂₂BrNO₅S
Molecular Weight:492.39
Hs Code.:

Synonyms:toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester

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Chemical Property of toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester

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Technology Process of toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester

There total 5 articles about toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

: 286441-93-8
toluene-4-sulfonic acid 2-amino-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester

: 286441-94-9
toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester

Guidance literature:: With hydrogen bromide; dimethyl sulfoxide; at 20 ℃;
DOI:10.1016/S0960-894X(00)00158-X

Reference yield:

: 2835-98-5
2-Hydroxy-4-methylanilin

: 286441-94-9
toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / triethylamine / CH₂Cl₂ / 20 °C

2: 80 percent / HBr; DMSO / H₂O / Heating

3: 99 percent / Pd(PPh₃)4; Na₂CO₃ / benzene; H₂O; ethanol / 8 h / Heating

4: 79.5 percent / HBr; DMSO / H₂O / 96 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; sodium carbonate; dimethyl sulfoxide; triethylamine; In ethanol; dichloromethane; water; benzene; 3: Suzuki cross-coupling;
DOI:10.1016/S0040-4020(00)00634-7

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 286441-94-9
toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / triethylamine / CH₂Cl₂ / 20 °C

2: 80 percent / HBr; DMSO / H₂O / Heating

3: 99 percent / Pd(PPh₃)4; Na₂CO₃ / benzene; H₂O; ethanol / 8 h / Heating

4: 79.5 percent / HBr; DMSO / H₂O / 96 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; sodium carbonate; dimethyl sulfoxide; triethylamine; In ethanol; dichloromethane; water; benzene; 3: Suzuki cross-coupling;
DOI:10.1016/S0040-4020(00)00634-7