S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate

Base Information

• Chemical Name: S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate
• CAS No.: 1174889-96-3
• Molecular Formula: C₃₄H₃₃NO₆S
• Molecular Weight: 583.705
• Mol file: 1174889-96-3.mol

Synonyms:S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate

Chemical Property of S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate

There total 1 articles about S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-Fmoc L-Phe (35661-40-6) + (2,4,6-trimethoxyphenyl)methanethiol (212555-23-2) → S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate (1174889-96-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 1h;

DOI:10.1021/ol901370y

Reference yield: 73.0%

Hexyl isocyanate (2525-62-4,26746-07-6) + S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate (1174889-96-3) → N-fluoren-9-ylmethoxycarbonyl-L-phenylalanine hexylamide (1174889-97-4)

Guidance literature:

S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Hexyl isocyanate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/ol901370y

Reference yield: 68.0%

S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate (1174889-96-3) + N-carbonyl-L-leucine methyl ester (30293-88-0,56753-77-6,39570-63-3) → methyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-L-leucinate

Guidance literature:

S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

N-carbonyl-L-leucine methyl ester; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/ol901370y

upstream raw materials:

N-Fmoc L-Phe

(2,4,6-trimethoxyphenyl)methanethiol

Downstream raw materials:

methyl 3,4,6-tri-O-acetyl-2-N-(N'-fluoren-9-ylmethoxycarbonyl-L-phenylalaninyl)-β-D-glucopyranoside

N-fluoren-9-ylmethoxycarbonyl-L-phenylalanine hexylamide

N-fluoren-9-ylmethoxycarbonyl-L-phenylalanine anilide

N-fluoren-9-ylmethoxycarbonyl-L-phenylalanine 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamide