(3-{[(16β,17β)-17-hydroxy-3-(hydroxymethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide)

Base Information

Chemical Name:(3-{[(16β,17β)-17-hydroxy-3-(hydroxymethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide)
CAS No.:1318265-15-4
Molecular Formula:C₂₇H₃₃NO₃
Molecular Weight:419.564
Hs Code.:

Synonyms:(3-{[(16β,17β)-17-hydroxy-3-(hydroxymethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide)

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Chemical Property of (3-{[(16β,17β)-17-hydroxy-3-(hydroxymethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide)

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Technology Process of (3-{[(16β,17β)-17-hydroxy-3-(hydroxymethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide)

There total 7 articles about (3-{[(16β,17β)-17-hydroxy-3-(hydroxymethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1318265-20-1
(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-triene-3-carboxylic acid

: 1318265-15-4
(3-{[(16β,17β)-17-hydroxy-3-(hydroxymethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide)

Guidance literature:: With sodium tetrahydroborate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 2455-37-0
(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid

: 1318265-15-4
(3-{[(16β,17β)-17-hydroxy-3-(hydroxymethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide)

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 0.5 h / Reflux

2.1: sodium tetrahydroborate / methanol; dichloromethane / 1 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 36 h / 20 °C

4.1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4.2: 20 °C

With sodium tetrahydroborate; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml200093v

Reference yield:

: 126534-87-0
3-carboxamidobenzaldehyde

: 1318265-15-4
(3-{[(16β,17β)-17-hydroxy-3-(hydroxymethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide)

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 0.5 h / Reflux

2.1: sodium tetrahydroborate / methanol; dichloromethane / 1 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 36 h / 20 °C

4.1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4.2: 20 °C

With sodium tetrahydroborate; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml200093v