ethyl 3-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate

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Chemical Name:ethyl 3-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate
CAS No.:1338811-29-2
Molecular Formula:C₃₈H₃₃N₅O₇S
Molecular Weight:703.775
Hs Code.:

Synonyms:ethyl 3-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate

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Chemical Property of ethyl 3-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate

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Technology Process of ethyl 3-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate

There total 5 articles about ethyl 3-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262309-88-5
5-(phenylsulfonyl)-7-(trimethylstannyl)-5H-pyrrolo[2,3-b]pyrazine

: 1338811-24-7
ethyl 3-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate

: 1338811-29-2
ethyl 3-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate

Guidance literature:: With cesium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; at 90 ℃; for 4h; Inert atmosphere;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1338811-29-2
ethyl 3-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 115 °C / Inert atmosphere

3.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

With sodium hydride; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 56015-31-7
7-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1338811-29-2
ethyl 3-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 115 °C / Inert atmosphere

3.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

With sodium hydride; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;