Formamide, N-methyl-N-4-pyridinyl- (9CI)

Base Information

• Chemical Name: Formamide, N-methyl-N-4-pyridinyl- (9CI)
• CAS No.: 284491-66-3
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.153
• Mol file: 284491-66-3.mol

Synonyms:N-methyl-N-(pyridin-4-yl)formamide

Chemical Property of Formamide, N-methyl-N-4-pyridinyl- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Formamide, N-methyl-N-4-pyridinyl- (9CI)

There total 5 articles about Formamide, N-methyl-N-4-pyridinyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(Methylamino)pyridine (1121-58-0) + carbon dioxide (124-38-9,18923-20-1) → N-methyl-N-(pyridin-4-yl)formamide (284491-66-3)

Guidance literature:

With sodium (phenyltrihydroxyborate); phenylsilane; In diethylene glycol dimethyl ether; at 60 ℃; for 12h; under 1875.19 Torr; Sealed tube; Glovebox; Autoclave;

DOI:10.1039/d0gc01741h

Reference yield: 26.0%

dmap (1122-58-3) → 4-(Methylamino)pyridine (1121-58-0) + N-methyl-N-(pyridin-4-yl)formamide (284491-66-3)

Guidance literature:

With tert.-butylhydroperoxide; manganese(II) acetate; trifluoroacetic acid; In benzene; at 70 ℃; for 16h; under 15001.5 Torr; chemoselective reaction; Mechanism;

DOI:10.1039/c4cy00255e

Reference yield:

4-(Methylamino)pyridine (1121-58-0) + carbon dioxide (124-38-9,18923-20-1) → C13H16N4 + N-methyl-N-(pyridin-4-yl)formamide (284491-66-3)

Guidance literature:

With phenylsilane; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In [D₃]acetonitrile; at 80 ℃; for 21h; under 750.075 Torr; chemoselective reaction;

DOI:10.1021/acscatal.5b00734

upstream raw materials:

4-formamidopyridine

methyl iodide

4-aminopyridine

dmap

Downstream raw materials:

dmap

4-(Methylamino)pyridine

Refernces

• 1、 Frogneux, Xavier,Blondiaux, Enguerrand,Thuéry, Pierre,Cantat, Thibault. "Bridging amines with CO2: Organocatalyzed reduction of CO2 to aminals". . p. 3983 - 3987. Retrieved 2015/11/11.
• 2、 Cheng, Ying,Liu, Qing-Xiang,Meth-Cohn, Otto. "Surprising formylations with methylformamidopyridines and oxalyl chloride". . p. 3475 - 3478. Retrieved 2007/10/03.