ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate

Base Information

• Chemical Name: ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate
• CAS No.: 321904-80-7
• Molecular Formula: C₁₉H₂₅NO₅
• Molecular Weight: 347.411
• Mol file: 321904-80-7.mol

Synonyms:ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate

Chemical Property of ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate

There total 1 articles about ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

benzyl bromide (100-39-0) + ethyl 3-<1-(methoxycarbonyl)-4-piperidyl>-3-oxopropanoate (167414-69-9) → ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate (321904-80-7)

Guidance literature:

With sodium ethanolate; In ethanol; at 80 ℃;

DOI:10.1021/jm000371q

Reference yield: 43.0%

ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate (321904-80-7) → 4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol (321904-89-6)

Guidance literature:

ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate; With sodium hydroxide; hydroxylamine hydrochloride; In methanol; water; at -30 ℃;

With hydrogenchloride; In methanol; water; at 80 ℃; Further stages.;

DOI:10.1021/jm000371q

Reference yield:

ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate (321904-80-7) → 4-benzyl-5-piperidin-4-yl-isoxazol-3-ol; hydrobromide

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; NaOH / methanol; H₂O / -30 °C

1.2: 43 percent / conc. HCl / H₂O; methanol / 80 °C

2.1: 53 percent / HBr / acetic acid / 20 °C

With sodium hydroxide; hydroxylamine hydrochloride; hydrogen bromide; In methanol; water; acetic acid;

DOI:10.1021/jm000371q

upstream raw materials:

benzyl bromide

ethyl 3-<1-(methoxycarbonyl)-4-piperidyl>-3-oxopropanoate

Downstream raw materials:

4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol