4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol

Base Information

• Chemical Name: 4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol
• CAS No.: 321904-89-6
• Molecular Formula: C₁₇H₂₀N₂O₄
• Molecular Weight: 316.357
• Mol file: 321904-89-6.mol

Synonyms:4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol

Chemical Property of 4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Methyl4-(4-benzyl-3-hydroxyisoxazol-5-yl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol

There total 5 articles about 4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate (321904-80-7) → 4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol (321904-89-6)

Guidance literature:

ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate; With sodium hydroxide; hydroxylamine hydrochloride; In methanol; water; at -30 ℃;

With hydrogenchloride; In methanol; water; at 80 ℃; Further stages.;

DOI:10.1021/jm000371q

Reference yield: 43.0%

methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate (439944-52-2) → 4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol (321904-89-6)

Guidance literature:

methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate; With sodium hydroxide; hydroxylamine hydrochloride; In methanol; at -30 ℃; for 2h;

With hydrogenchloride; In methanol; at 80 ℃; for 2h; Further stages.;

DOI:10.1021/jm020027o

Reference yield:

ethyl 3-<1-(methoxycarbonyl)-4-piperidyl>-3-oxopropanoate (167414-69-9) → 4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol (321904-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 60 percent / methanol / 16 h / Heating

2.1: NH₂OH*HCl; aq. NaOH / methanol / 2 h / -30 °C

2.2: 43 percent / aq. HCl / methanol / 2 h / 80 °C

With sodium hydroxide; hydroxylamine hydrochloride; In methanol;

DOI:10.1021/jm020027o

upstream raw materials:

ethyl 4-(1-methoxycarbonyl-4-piperidyl)-2-benzyl-3-oxopropionate

methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

ethyl 3-<1-(methoxycarbonyl)-4-piperidyl>-3-oxopropanoate

1-methoxycarbonyl-4-piperidinecarboxylic acid chloride