Trifluoro-acetic acid phenylsulfanylmethyl ester

Base Information

• Chemical Name: Trifluoro-acetic acid phenylsulfanylmethyl ester
• CAS No.: 103603-55-0
• Molecular Formula: C₉H₇F₃O₂S
• Molecular Weight: 236.215
• Mol file: 103603-55-0.mol

Synonyms:Trifluoro-acetic acid phenylsulfanylmethyl ester

Chemical Property of Trifluoro-acetic acid phenylsulfanylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Trifluoro-acetic acid phenylsulfanylmethyl ester

There total 11 articles about Trifluoro-acetic acid phenylsulfanylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

racemic methyl phenyl sulfoxide (1193-82-4) + trifluoroacetic anhydride (407-25-0) → Trifluoro-acetic acid phenylsulfanylmethyl ester (103603-55-0)

Guidance literature:

In acetonitrile; at 25 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1021/ja2031882

Reference yield: 46.0%

racemic methyl phenyl sulfoxide (1193-82-4) + trifluoroacetic anhydride (407-25-0) → bis(phenylthio)methane (3561-67-9) + N-<(phenylsulfenyl)methyl>benzamide (58379-67-2) + Trifluoro-acetic acid phenylsulfanylmethyl ester (103603-55-0)

Guidance literature:

With benzonitrile; trifluoroacetic acid; In dichloromethane; 1) 0 deg C, 8 h, 2) r.t., 72 h;

DOI:10.1016/S0040-4020(01)96692-X

Reference yield: 45.0%

racemic methyl phenyl sulfoxide (1193-82-4) + acetonitrile (75-05-8,26809-02-9) + trifluoroacetic anhydride (407-25-0) → bis(phenylthio)methane (3561-67-9) + N-Phenylsulfanylmethyl-acetamide (75893-06-0) + Trifluoro-acetic acid phenylsulfanylmethyl ester (103603-55-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 56h; Product distribution; Mechanism; 1) 0 deg C, 8 h, 2) r.t., 48 h; (investigation of various further sulfoxides and nitriles);

DOI:10.1016/S0040-4020(01)96692-X

upstream raw materials:

racemic methyl phenyl sulfoxide

benzonitrile

acrylonitrile

acetonitrile

Downstream raw materials:

benzenesulfonyl chloride

Refernces

• 1、 Huang, Xueliang,Patil, Mahendra,Fares, Christophe,Thiel, Walter,Maulide, Nuno. "Sulfur(IV)-mediated transformations: From ylide transfer to metal-free arylation of carbonyl compounds". . p. 7312 - 7323. Retrieved 2013/06/26.
• 2、 Huang, Xueliang,Maulide, Nuno. "Sulfoxide-mediated α-arylation of carbonyl compounds". scheme or table. p. 8510 - 8513. Retrieved 2011/07/09.