2-ethoxy-6-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid

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Chemical Name:2-ethoxy-6-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid
CAS No.:1356060-02-0
Molecular Formula:C₂₆H₂₃NO₅
Molecular Weight:429.472
Hs Code.:

Synonyms:2-ethoxy-6-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid

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Chemical Property of 2-ethoxy-6-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid

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Technology Process of 2-ethoxy-6-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid

There total 5 articles about 2-ethoxy-6-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 451-40-1
phenyl benzyl ketone

: 1283119-50-5
methyl 2-ethoxy-4-formyl-6-hydroxybenzoate

: 631-61-8,92206-38-7
ammonium acetate

: 1356060-02-0
2-ethoxy-6-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid

Guidance literature:: phenyl benzyl ketone; methyl 2-ethoxy-4-formyl-6-hydroxybenzoate; ammonium acetate; With cycl-isopropylidene malonate; acetic acid; Reflux; Inert atmosphere;

With water; sodium hydroxide; In methanol; at 70 ℃; for 5h; Inert atmosphere;

With hydrogenchloride; In methanol; water; at 20 ℃; pH=3;

Reference yield:

: 1283120-09-1
methyl 2,6-diethoxy-4-formylbenzoate

: 1356060-02-0
2-ethoxy-6-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / dichloromethane / 0.08 h / 10 °C / Reflux

2.1: cycl-isopropylidene malonate; acetic acid / Reflux; Inert atmosphere

2.2: 5 h / 70 °C / Inert atmosphere

2.3: 20 °C / pH 3

With aluminum (III) chloride; cycl-isopropylidene malonate; acetic acid; In dichloromethane;

Reference yield:

: 16534-12-6
3,5-dihydroxy-4-bromobenzoic acid

: 1356060-02-0
2-ethoxy-6-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: Saturated solution

3.1: triethylamine; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 72 h / 120 °C / 37503.8 Torr

4.1: manganese(IV) oxide / dichloromethane / 1 h / Reflux

5.1: aluminum (III) chloride / dichloromethane / 0.08 h / 10 °C / Reflux

6.1: cycl-isopropylidene malonate; acetic acid / Reflux; Inert atmosphere

6.2: 5 h / 70 °C / Inert atmosphere

6.3: 20 °C / pH 3

With manganese(IV) oxide; aluminum (III) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; cycl-isopropylidene malonate; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;