*,R^*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester

Base Information

• Chemical Name: *,R^*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester
• CAS No.: 117085-66-2
• Molecular Formula: C₃₆H₃₆N₂O₆
• Molecular Weight: 592.692

Synonyms:*,R^*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester

Chemical Property of *,R^*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester

Chemical Property:

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Technology Process of *,R^*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester

There total 4 articles about *,R^*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid (59221-35-1) → *,R*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester (117085-66-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 1 h / 0 °C

2: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

3: 1.0 N LiOH / dioxane / 16 h / Ambient temperature

4: ethyl acetate / 1.5 h / Ambient temperature

With dmap; lithium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

DOI:10.1021/jm00167a028

Reference yield:

(S)-6-Benzyloxycarbonylamino-2-(2,2-dimethyl-propionyloxy)-hexanoic acid (126111-16-8) → *,R*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester (117085-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

2: 1.0 N LiOH / dioxane / 16 h / Ambient temperature

3: ethyl acetate / 1.5 h / Ambient temperature

With dmap; lithium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

DOI:10.1021/jm00167a028

Reference yield:

Ethyl (S)-indoline-2-carboxylate hydrochloride (79854-42-5) → *,R*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester (117085-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

2: 1.0 N LiOH / dioxane / 16 h / Ambient temperature

3: ethyl acetate / 1.5 h / Ambient temperature

With dmap; lithium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

DOI:10.1021/jm00167a028

upstream raw materials:

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

(S)-6-Benzyloxycarbonylamino-2-(2,2-dimethyl-propionyloxy)-hexanoic acid

Ethyl (S)-indoline-2-carboxylate hydrochloride

*,R^*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester

Downstream raw materials:

*,R^*)>-2,3-dihydro-1-<2-<oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester

*,R^*)>-2,3-dihydro-1-<6-amino-2-<oxy>-1-oxohexyl>-1H-indole-2-carboxylic acid

(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester

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