4-METHOXYBENZAMIDINE FOR FLUORESCENCE

Base Information

• Chemical Name: 4-METHOXYBENZAMIDINE FOR FLUORESCENCE
• CAS No.: 22265-37-8
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Hs Code.: 2925290090
• Mol file: 22265-37-8.mol

Synonyms:p-Methoxybenzamidine;p-Anisamidine(7CI,8CI);4-(Methyloxy)benzenecarboximidamide;4-Methoxybenzamidine;4-methoxybenzenecarboximidamide;benzenecarboximidamide, 4-methoxy-;

Chemical Property of 4-METHOXYBENZAMIDINE FOR FLUORESCENCE

Chemical Property:

• Vapor Pressure: 0.00487mmHg at 25°C
• Melting Point: 120-124 °C
• Refractive Index: 1.494
• Boiling Point: 255.1 °C at 760 mmHg
• Flash Point: 108.1 °C
• PSA: 59.10000
• Density: 1.13 g/cm³
• LogP: 1.77930
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxybenzamidine suitable for fluorescence, ≥96.0% (NT) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reagent for the determination of reducing carbohydrates and glycoproteins by postcolumn derivatization after HPLC; A method using benzamidine should be improved by this reagent

Technology Process of 4-METHOXYBENZAMIDINE FOR FLUORESCENCE

There total 18 articles about 4-METHOXYBENZAMIDINE FOR FLUORESCENCE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-methoxybenzonitrile (874-90-8) → 4-methoxybenzamidine (22265-37-8)

Guidance literature:

With amino(methyl)aluminum chloride; In toluene; at 80 ℃;

DOI:10.1016/S0040-4039(00)88891-7

Reference yield: 93.0%

4-methoxybenzamidoxime (5373-87-5) → 4-methoxybenzamidine (22265-37-8)

Guidance literature:

With hydrogen; nickel; acetic acid; In methanol; at 20 ℃; for 12h;

Reference yield: 70.0%

CYANAMID (420-04-2) + potassium 4-(methoxy)phenyltrifluoroborate → 4-methoxybenzamidine (22265-37-8)

Guidance literature:

With palladium(II) trifluoroacetate; trifluoroacetic acid; 6-methyl-2,2'-bipyridine; In methanol; at 120 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/ol300813c

upstream raw materials:

(Z)-para-methoxybenzaldehyde oxime

4-methoxy-benzaldehyde-(O-methyl-seqtrans-oxime )

4-methoxybenzonitrile

sodium thiophenolate

Downstream raw materials:

methyl 2-(4-methoxyphenyl)pyrimidine-5-carboxylate

2-(4-methoxy-phenyl)-4,6-diphenyl-[1,3,5]triazine

Refernces

• 1、 -. "Nortopsentin alkaloid derivatives and preparation thereof, and application of nortopsentin alkaloid derivatives to prevention and treatment of diseases and insect pests". . . Retrieved 2019/03/26.
• 2、 Bauch, Eva,Reichmann, Debora,Mendel, Ralf-Rainer,Bittner, Florian,Manke, Anne-Marie,Kurz, Philipp,Girreser, Ulrich,Havemeyer, Antje,Clement, Bernd. "Electrochemical and mARC-catalyzed enzymatic reduction of para-substituted benzamidoximes: Consequences for the prodrug concept "amidoximes instead of amidines"". . p. 360 - 367. Retrieved 2015/02/05.