DIETHYLENETRIAMINEPENTAACETIC DIANHYDRIDE

Base Information

• Chemical Name: DIETHYLENETRIAMINEPENTAACETIC DIANHYDRIDE
• CAS No.: 2311-26-4
• Molecular Formula: C₆H₁₁NO₄
• Molecular Weight: 161.158
• Mol file: 2311-26-4.mol

Synonyms:DL-Serine,N-acetyl-, methyl ester; N-Acetyl-DL-serine methyl ester

Chemical Property of DIETHYLENETRIAMINEPENTAACETIC DIANHYDRIDE

Chemical Property:

• Melting Point: 182-184 °C(lit.)
• PSA: 133.76000
• LogP: -2.98040
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

Diethylenetriaminepentaacetic dianhydride 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIETHYLENETRIAMINEPENTAACETIC DIANHYDRIDE

There total 13 articles about DIETHYLENETRIAMINEPENTAACETIC DIANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride (5680-80-8) + acetic acid (64-19-7,77671-22-8) → (S)-methyl 2-acetamido-3-hydroxypropanoate (2311-26-4,54322-41-7,55299-56-4,288402-26-6)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jo00049a019

Reference yield: 84.0%

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride (5680-80-8) + acetyl chloride (75-36-5) → (S)-methyl 2-acetamido-3-hydroxypropanoate (2311-26-4,54322-41-7,55299-56-4,288402-26-6)

Guidance literature:

With triethylamine; In dichloromethane; at -5 - 20 ℃; for 2h;

DOI:10.1016/j.tet.2008.07.015

Reference yield: 83.0%

(S)-serine methyl ester (2788-84-3) + benzylidene 1,1-diacetate (581-55-5) → (S)-methyl 2-acetamido-3-hydroxypropanoate (2311-26-4,54322-41-7,55299-56-4,288402-26-6)

Guidance literature:

In neat (no solvent); at 70 ℃; for 16h;

DOI:10.1016/j.tet.2018.05.044

upstream raw materials:

N-Acetyl-3-O-p-tolylsulfonyl-DL-serin-methylester

diazomethane

2-aminomalonic acid

acetic anhydride

Downstream raw materials:

N-acetyl-serine

2-acetamido-N-benzyl-3-methoxypropionamide

3-chloro-2-acetylamino-propionic acid methylester

(+)-2-acetamido-3-chloropropanoic acid methyl ester