5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

Base Information

Chemical Name:5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide
CAS No.:221385-28-0
Molecular Formula:C₂₂H₂₃Cl₂N₅O
Molecular Weight:444.364
Hs Code.:

5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1<i>H</i>-pyrazole-3-carboxylic acid piperidin-1-ylamide

Synonyms:5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

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Chemical Property of 5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

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Technology Process of 5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

There total 5 articles about 5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 221385-25-7
1-(2,4-dichloro-phenyl)-4-methyl-5-(4-nitro-phenyl)-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

: 221385-28-0
5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

Guidance literature:: With hydrazine; nickel; In ethanol; water; at 70 ℃; for 3h;
DOI:10.1021/jm980363y

Reference yield:

: 5446-18-4
2,4-dichlorophenyl hydrazine hydrochloride

: 221385-28-0
5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) AcOH / 1.) EtOH, RT, 20 h, 2.) reflux, 24 h

3: 94 percent / N₂H₄ / Raney Ni / ethanol; H₂O / 3 h / 70 °C

With acetic acid; hydrazine; nickel; In ethanol; water;
DOI:10.1021/jm980363y

Reference yield:

: 93-55-0
1-phenyl-propan-1-one

: 221385-28-0
5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LiHMDS / 1.) hexane, diethyl ether, -78 deg C, 45 min, 2.) hexane, diethyl ether, RT, 16 h

2: 2.) AcOH / 1.) EtOH, RT, 20 h, 2.) reflux, 24 h

4: 94 percent / N₂H₄ / Raney Ni / ethanol; H₂O / 3 h / 70 °C

With acetic acid; lithium hexamethyldisilazane; hydrazine; nickel; In ethanol; water;
DOI:10.1021/jm980363y