2-bromo-1-tetralone

Base Information

• Chemical Name: 2-bromo-1-tetralone
• CAS No.: 1056246-70-8
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225.085
• Mol file: 1056246-70-8.mol

Synonyms:2-bromo-1-tetralone

Chemical Property of 2-bromo-1-tetralone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-1-tetralone

There total 21 articles about 2-bromo-1-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 2-bromo-1-tetralone (1056246-70-8,13672-07-6)

Guidance literature:

With bromine; In diethyl ether; for 2h; -10 deg C -> RT;

DOI:10.3987/com-98-s(h)37

Reference yield: 96.0%

1-trimethylsiloxy-3,4-dihydronaphthalene (38858-72-9) → 2-bromo-1-tetralone (1056246-70-8,13672-07-6)

Guidance literature:

With lead(IV) acetate; sodium bromide; In methanol; at 0 ℃; for 0.166667h;

DOI:10.1055/s-1982-30047

Reference yield: 95.0%

3,4-dihydronaphthalen-1-yl acetate (19455-84-6) → 2-bromo-1-tetralone (1056246-70-8,13672-07-6)

Guidance literature:

With lead(IV) acetate; sodium bromide; In methanol; at 0 ℃; for 2h;

DOI:10.1055/s-1982-30047

upstream raw materials:

2-bromo-1-hydroxy-1,2,3,4-tetrahydronaphthalene

3,4-dihydronaphthalene-1(2H)-one

3,4-dihydronaphthalen-1-yl acetate

4-methoxy-1,2-dihydronaphthalene

Downstream raw materials:

cyclohexyl-(1-cyclohexyl-4,5-dihydro-1H-naphtho[1,2-d]thiazol-2-yliden)-amine

[2-(1-Oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-thiophen-3-yl]-carbamic acid tert-butyl ester

3,4-dihydronaphthalene-1(2H)-one

[2-(1-Oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzo[b]thiophen-3-yl]-carbamic acid tert-butyl ester

Refernces

• 1、 Marsh, Adam V.,Little, Mark,Cheetham, Nathan J.,Dyson, Matthew J.,Bidwell, Matthew,White, Andrew J. P.,Warriner, Colin N.,Swain, Anthony C.,McCulloch, Iain,Stavrinou, Paul N.,Heeney, Martin. "Highly Deformed o-Carborane Functionalised Non-linear Polycyclic Aromatics with Exceptionally Long C?C Bonds". supporting information. p. 1970 - 1975. Retrieved 2020/12/25.
• 2、 Grathwol, Christoph W.,W?ssner, Nathalie,Swyter, S?ren,Smith, Adam C.,Tapavicza, Enrico,Hofstetter, Robert K.,Bodtke, Anja,Jung, Manfred,Link, Andreas. "Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: Towards the design of photoswitchable sirtuin inhibitors". supporting information. p. 2170 - 2183. Retrieved 2019/09/30.