2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)-N-(2-hydroxyethyl)acetamide

Base Information

Chemical Name:2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)-N-(2-hydroxyethyl)acetamide
CAS No.:1606975-07-8
Molecular Formula:C₂₂H₂₂ClN₅O₂
Molecular Weight:423.902
Hs Code.:

Synonyms:2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)-N-(2-hydroxyethyl)acetamide

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Chemical Property of 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)-N-(2-hydroxyethyl)acetamide

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Technology Process of 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)-N-(2-hydroxyethyl)acetamide

There total 6 articles about 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)-N-(2-hydroxyethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1606975-05-6
2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetic acid

: 141-43-5
ethanolamine

: 1606975-07-8
2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)-N-(2-hydroxyethyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

Reference yield:

: 25412-62-8
3-chlorobenzimidamide

: 1606975-07-8
2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)-N-(2-hydroxyethyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / ethanol / 20 h / 0 °C / Reflux

2.1: trichlorophosphate / 1.5 h / 0 - 100 °C

3.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere; Microwave irradiation

4.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1.5 h / 50 °C

4.2: pH Ca_. 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 0 °C

With lithium hydroxide monohydrate; water; sodium methylate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; trichlorophosphate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 24922-02-9
Ethyl 3-cyclopropyl-3-oxopropionate

: 1606975-07-8
2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)-N-(2-hydroxyethyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / ethanol / 20 h / 0 °C / Reflux

2.1: trichlorophosphate / 1.5 h / 0 - 100 °C

3.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere; Microwave irradiation

4.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1.5 h / 50 °C

4.2: pH Ca_. 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 0 °C

With lithium hydroxide monohydrate; water; sodium methylate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; trichlorophosphate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;