tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane

Base Information

Chemical Name:tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane
CAS No.:1313731-47-3
Molecular Formula:C₃₇H₅₂BrNO₂Si
Molecular Weight:650.815
Hs Code.:

Synonyms:tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane

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Chemical Property of tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane

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Technology Process of tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane

There total 6 articles about tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1313731-46-2
tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-isopropylphenyl)butan-1-oxy)dimethylsilane

: 1313731-47-3
tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane

Guidance literature:: With N-Bromosuccinimide; dihydrogen peroxide; In tetrachloromethane; for 4h; Reflux;
DOI:10.1080/00397911.2010.502986

Reference yield:

: 98-82-8
Isopropylbenzene

: 1313731-47-3
tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / -10 °C

1.2: 10 h / 5 - 20 °C

2.1: potassium hydrogencarbonate / 5,5-dimethyl-1,3-cyclohexadiene; water / 12 h / Reflux

3.1: sodium tetrahydroborate / methanol / 0.5 h / Cooling with ice

4.1: 1H-imidazole / N,N-dimethyl-formamide / 10.25 h / 0 - 20 °C / Inert atmosphere

5.1: N-Bromosuccinimide; dihydrogen peroxide / tetrachloromethane / 4 h / Reflux

With 1H-imidazole; aluminum (III) chloride; sodium tetrahydroborate; N-Bromosuccinimide; dihydrogen peroxide; potassium hydrogencarbonate; In methanol; tetrachloromethane; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Friedel Crafts acylation / 1.2: Friedel Crafts acylation;
DOI:10.1080/00397911.2010.502986

Reference yield:

: 115-46-8
C₁₈H₂₁NO

: 1313731-47-3
tert-butyl(4-(4-(hydroxyldiphenylmethyl)piperidin-1-yl)-1-(4-(2-bromopropan-2-yl)phenyl)butan-1-oxy)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydrogencarbonate / 5,5-dimethyl-1,3-cyclohexadiene; water / 12 h / Reflux

2: sodium tetrahydroborate / methanol / 0.5 h / Cooling with ice

3: 1H-imidazole / N,N-dimethyl-formamide / 10.25 h / 0 - 20 °C / Inert atmosphere

4: N-Bromosuccinimide; dihydrogen peroxide / tetrachloromethane / 4 h / Reflux

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; dihydrogen peroxide; potassium hydrogencarbonate; In methanol; tetrachloromethane; 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide;
DOI:10.1080/00397911.2010.502986