N-(3-{[(2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl)(methyl)amino]methyl}phenyl)urea

Base Information

Chemical Name:N-(3-{[(2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl)(methyl)amino]methyl}phenyl)urea
CAS No.:956234-68-7
Molecular Formula:C₂₅H₃₂N₄O₄
Molecular Weight:452.553
Hs Code.:

Synonyms:N-(3-{[(2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl)(methyl)amino]methyl}phenyl)urea

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Chemical Property of N-(3-{[(2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl)(methyl)amino]methyl}phenyl)urea

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Technology Process of N-(3-{[(2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl)(methyl)amino]methyl}phenyl)urea

There total 9 articles about N-(3-{[(2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl)(methyl)amino]methyl}phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 956234-67-6
(3-methylaminomethyl-phenyl)-urea

: 956234-36-9
2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl methanesulfonate

: 956234-68-7
N-(3-{[(2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl)(methyl)amino]methyl}phenyl)urea

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃; for 72h;

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 956234-68-7
N-(3-{[(2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl)(methyl)amino]methyl}phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / tetrabutylammomium bromide / water / 5 h / 20 °C

2: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 3 h / 75 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 2070.21 Torr

4: triethylamine / dichloromethane / 20 °C

5: sodium hydrogencarbonate / N,N-dimethyl-formamide / 72 h / 70 °C

With sodium hydroxide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium 10% on activated carbon; tetrabutylammomium bromide; cetyltributylphosphonium bromide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 943742-18-5
(3-amino-benzyl)-methyl-carbamic acid benzyl ester

: 956234-68-7
N-(3-{[(2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl)(methyl)amino]methyl}phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: water; acetic acid / 0.5 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 2070.21 Torr

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 72 h / 70 °C

With hydrogen; sodium hydrogencarbonate; palladium 10% on activated carbon; In methanol; water; acetic acid; N,N-dimethyl-formamide;