Ac-LYRANV-S(CH₂)₂CO₂Et

Base Information

• Chemical Name: Ac-LYRANV-S(CH₂)₂CO₂Et
• CAS No.: 1186032-43-8
• Molecular Formula: C₄₀H₆₄N₁₀O₁₁S
• Molecular Weight: 893.075
• Mol file: 1186032-43-8.mol

Synonyms:Ac-LYRANV-S(CH₂)₂CO₂Et

Chemical Property of Ac-LYRANV-S(CH₂)₂CO₂Et

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ac-LYRANV-S(CH₂)₂CO₂Et

There total 1 articles about Ac-LYRANV-S(CH₂)₂CO₂Et which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

3-mercaptopropionic acid ethyl ester (5466-06-8) + Fmoc-Val-OH (68858-20-8) + Fmoc-Leu-OH (35661-60-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + L-Asn(Trt) (132388-59-1) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → Ac-LYRANV-S(CH2)2CO2Et (1186032-43-8)

Guidance literature:

Fmoc-Val-OH; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

With piperidine; In N,N-dimethyl-formamide;

3-mercaptopropionic acid ethyl ester; Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Tyr(tBu)-OH; L-Asn(Trt); Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; acetylated derivative; Further stages;

DOI:10.1021/ja502806r

Reference yield: 87.0%

Ac-LYRANV-S(CH2)2CO2Et (1186032-43-8) + H-(β-SH)FSPGYS-NH2 → Ac-LYRANV(β-SH)FSPGYS-NH2

Guidance literature:

With 2,2,2-trifluoroethanethiol;

DOI:10.1021/acs.orglett.5b00597

Reference yield: 75.0%

Ac-LYRANV-S(CH2)2CO2Et (1186032-43-8) + H-(β-SH)DSPGYS-NH2 (1460214-03-2) → Ac-LYRANVD(β-SH)SPGYS-NH2 (1460214-35-0)

Guidance literature:

With thiophenol; In aq. buffer; at 37 ℃; pH=7.3 - 7.5; Inert atmosphere;

DOI:10.1002/anie.201304793

upstream raw materials:

3-mercaptopropionic acid ethyl ester

Fmoc-Val-OH

Fmoc-Leu-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Downstream raw materials:

C₆₀H₉₂N₁₇O₂₂P

C₆₁H₉₄N₁₇O₂₂P

Ac-LYRANVESPGYS-NH₂

Ac-LYRANVDSPGYS-NH₂