3-(2,4-dimethoxyphenyl)propanoic Acid

Base Information

• Chemical Name: 3-(2,4-dimethoxyphenyl)propanoic Acid
• CAS No.: 22174-29-4
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID00397629
• Nikkaji Number: J523.066G
• Wikidata: Q72468372
• Mol file: 22174-29-4.mol

Synonyms:3-(2,4-dimethoxyphenyl)propanoic Acid;22174-29-4;3-(2,4-Dimethoxyphenyl)propionic acid;2,4-Dimethoxy-benzenepropanoic acid;Benzenepropanoic acid,2,4-dimethoxy-;SCHEMBL490637;DTXSID00397629;MFCD00598205;STL302114;3-(2,4-dimethoxyphenyl)propanoicAcid;AKOS000193324;3-(2,4-dimethoxyphenyl) propionic acid;AS-63442;FT-0654763;3-(2,4-Dimethoxyphenyl)propionic acid, 97%;3-(2 4-DIMETHOXYPHENYL)PROPIONIC ACID;EN300-265755;F52928;A815993;J-014565;F9995-0943

Chemical Property of 3-(2,4-dimethoxyphenyl)propanoic Acid

Chemical Property:

• Vapor Pressure: 1.48E-05mmHg at 25°C
• Melting Point: 100-104 °C(lit.)
• Refractive Index: 1.522
• Boiling Point: 351.9 °C at 760 mmHg
• PKA: 4.79±0.10(Predicted)
• Flash Point: 135.6 °C
• PSA: 55.76000
• Density: 1.159 g/cm³
• LogP: 1.72100
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 210.08920892
• Heavy Atom Count: 15
• Complexity: 205

Purity/Quality:

97% ^*data from raw suppliers

3-(2,4-Dimethoxyphenyl)propionic acid ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CCC(=O)O)OC
• Uses: 3-(2,4-Dimethoxyphenyl)propionic Acid acts as a synthetic reagent in the preparation of acylaminopyridinylimidazoles as p38 MAP kinase inhibitors

Technology Process of 3-(2,4-dimethoxyphenyl)propanoic Acid

There total 9 articles about 3-(2,4-dimethoxyphenyl)propanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

acrylic acid (79-10-7) + 1,3-Dimethoxybenzene (151-10-0) → 3-(2,4-dimethoxyphenyl) propionic acid (22174-29-4)

Guidance literature:

With toluene-4-sulfonic acid; at 125 ℃; for 3h;

DOI:10.1016/j.tetlet.2007.05.059

Reference yield:

(E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid (16909-09-4) → 3-(2,4-dimethoxyphenyl) propionic acid (22174-29-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo00382a018

Reference yield:

recorcinol (108-46-3) → 3-(2,4-dimethoxyphenyl) propionic acid (22174-29-4)

Guidance literature:

Multi-step reaction with 2 steps

2: NaOH-solution

With sodium hydroxide;

upstream raw materials:

2,4-dimethoxycinnamic acid

3-(2,4-Dihydroxyphenyl)propionic Acid

dimethyl sulfate

methyl-3-(2,4-dimethoxyphenyl)propanoate

Downstream raw materials:

2,4-dimethoxyphenethylamine

(2,4-dimethoxy-phenethyl)-methyl-amine

(S)-2-(3-(2,4-dimethoxyphenyl)propanoyl)-N-methyl-N-(4-(3-oxomorpholino)phenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

1-bromo-3-(2,4-dimethoxyphenyl)propane