ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4,5-dihydro-3H-pyrrole-3-carboxylate

Base Information

• Chemical Name: ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4,5-dihydro-3H-pyrrole-3-carboxylate
• CAS No.: 173864-46-5
• Molecular Formula: C₂₁H₂₁NO₅
• Molecular Weight: 367.401
• Mol file: 173864-46-5.mol

Synonyms:ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4,5-dihydro-3H-pyrrole-3-carboxylate

Chemical Property of ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4,5-dihydro-3H-pyrrole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4,5-dihydro-3H-pyrrole-3-carboxylate

There total 7 articles about ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4,5-dihydro-3H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate (173864-45-4) → ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4,5-dihydro-3H-pyrrole-3-carboxylate (173864-46-5)

Guidance literature:

With hydrogen; nickel; In ethanol; under 3040 Torr;

DOI:10.1021/jm9505369

Reference yield:

ethyl 4-methoxybenzoylacetate (2881-83-6) → ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4,5-dihydro-3H-pyrrole-3-carboxylate (173864-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: DBU / tetrahydrofuran; propan-2-ol

2: H₂ / Ra-Ni / tetrahydrofuran; acetic acid

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; Ra-Ni; In tetrahydrofuran; acetic acid; isopropyl alcohol;

DOI:10.1021/jm970101g

Reference yield:

piperonal (120-57-0,30024-74-9) → ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4,5-dihydro-3H-pyrrole-3-carboxylate (173864-46-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₄OAc / acetic acid / Heating

2: DBU / tetrahydrofuran; propan-2-ol

3: H₂ / Ra-Ni / tetrahydrofuran; acetic acid

With ammonium acetate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; Ra-Ni; In tetrahydrofuran; acetic acid; isopropyl alcohol;

DOI:10.1021/jm970101g

upstream raw materials:

Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate

piperonal

5-((E)-2-nitroethenyl)-1,3-benzodioxole

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

(2S,4S)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

(2R,3S,4S)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

ethyl c-(1,3-benzodioxol-5-yl)-r-2-(4-methoxyphenyl)pyrrolidine-t-3-carboxylate

4-Benzo[1,3]dioxol-5-yl-1-(2-isobutylamino-ethyl)-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester