Technology Process of bis(benzeneacetic acid) 2',3',5',6'-tetrahydroxy[1,1':4',1''-terphenyl]-4,4''-diyl ester
There total 6 articles about bis(benzeneacetic acid) 2',3',5',6'-tetrahydroxy[1,1':4',1''-terphenyl]-4,4''-diyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium dihydroxide;
In
methanol; ethyl acetate;
at 20 ℃;
for 9.5h;
DOI:10.1021/ol701590b
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / dimethylformamide / 0.5 h / 0 °C
1.2: 2.50 g / dimethylformamide / 14 h / 0 - 14 °C
2.1: 83 percent / Na2CO3; Ph3P / Pd(OAc)2 / propan-1-ol; H2O / 11 h / 100 °C
3.1: 79 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h / 20 °C
4.1: 81 percent / H2 / Pd(OH)2 / ethyl acetate; methanol / 9.5 h / 20 °C
With
n-butyllithium; hydrogen; sodium hydride; sodium carbonate; triphenylphosphine;
palladium diacetate; palladium dihydroxide;
In
tetrahydrofuran; methanol; propan-1-ol; hexane; water; ethyl acetate; N,N-dimethyl-formamide;
2.1: Suzuki coupling;
DOI:10.1021/ol701590b
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 79 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h / 20 °C
2: 81 percent / H2 / Pd(OH)2 / ethyl acetate; methanol / 9.5 h / 20 °C
With
n-butyllithium; hydrogen;
palladium dihydroxide;
In
tetrahydrofuran; methanol; hexane; ethyl acetate;
DOI:10.1021/ol701590b
