8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Name:8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1395882-34-4
Molecular Formula:C₂₈H₂₆ClF₃N₆O₄
Molecular Weight:603
Hs Code.:

8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Synonyms:8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Property of 8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Technology Process of 8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 3 articles about 8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 86386-76-7,123632-22-4,141113-42-0,150024-48-9
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

: 105956-97-6,117404-52-1
clinafloxacin

: 1395882-34-4
8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole; clinafloxacin; With sodium hydrogencarbonate; In ethanol; at 70 ℃; for 18h;

With formic acid; In ethanol; at 20 ℃; pH=5.5 - 6.5;
DOI:10.1016/j.bmcl.2012.07.064

Reference yield:

: 372-18-9
1,3-Difluorobenzene

: 1395882-34-4
8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane / 20 °C

2.1: potassium carbonate / acetonitrile / 20 - 80 °C

3.1: sodium hydroxide / toluene / 60 °C

4.1: sodium hydrogencarbonate / ethanol / 18 h / 70 °C

4.2: 20 °C / pH 5.5 - 6.5

With aluminum (III) chloride; sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; In ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.07.064

Reference yield:

: 51336-94-8
2-chloro-1-(2,4-dichlorophenyl)ethanone

: 1395882-34-4
8-chloro-1-cyclopropyl-7-(3-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylamino)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 20 - 80 °C

2.1: sodium hydroxide / toluene / 60 °C

3.1: sodium hydrogencarbonate / ethanol / 18 h / 70 °C

3.2: 20 °C / pH 5.5 - 6.5

With sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; In ethanol; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.07.064