(S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one

Base Information

Chemical Name:(S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one
CAS No.:1453082-84-2
Molecular Formula:C₃₄H₃₈F₃N₇O₄Si
Molecular Weight:693.801
Hs Code.:

Synonyms:(S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one

There total 6 articles about (S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944401-58-5
5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))-4-(trifluoromethyl)pyrimidine-2-ylamine

: 1453082-85-3
(S)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-3-(6-chloro-2-(morpholin-4-yl)pyrimidin-4-yl)-[1,3]oxazinan-2-one

: 1453082-84-2
(S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; at 120 ℃; for 0.25h; Inert atmosphere;

Reference yield:

: 606129-40-2
(S)-3-(((tert-butoxy)carbonyl)amino)-4-(((tert-butyldiphenyl)silanyl)oxy)butyric acid benzyl ester

: 1453082-84-2
(S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran; tert-butyl methyl ether / 5.26 h / 0 - 20 °C

2: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 2.5 h / 115 °C / Inert atmosphere

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 0.25 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium borohydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; tert-butyl methyl ether; mineral oil;

Reference yield:

: 606129-43-5
[(S)-1-(((tert-butyldiphenyl)silanyl)oxymethyl)-3-hydroxypropyl]carbamic acid tert-butyl ester

: 1453082-84-2
(S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 2.5 h / 115 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 0.25 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; mineral oil;