606129-40-2

Upstream product

• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 84890-97-1 (S)-3-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester 
• 79069-16-2 benzyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 606129-43-5 [(S)-1-(((tert-butyldiphenyl)silanyl)oxymethyl)-3-hydroxypropyl]carbamic acid tert-butyl ester 
• 1453082-84-2 (S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one 
• 1453082-85-3 (S)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-3-(6-chloro-2-(morpholin-4-yl)pyrimidin-4-yl)-[1,3]oxazinan-2-one 
• 1453082-86-4 (S)-4-(((tert-butyldiphenyl)silanyl)oxymethyl)-[1,3]oxazinan-2-one 

Relevant academic research and scientific papers

Lipidated cyclopropenes via a stable 3-N spirocyclopropene scaffold

Lipidated cyclopropenes serve as useful bioorthogonal reagents for imaging cell membranes due to the cyclopropene's small size and ability to ligate with pro-fluorescent tetrazines. Previously, the lipidation of cyclopropenes required modification at the C3 position because methods to append lipids at C1/C2 were not available. Herein, we describe C1/C2 lipidation with the biologically active lipid ceramide and a common phospholipid using a cyclopropene scaffold whose reactivity with 1,2,4,5-tetrazines has been caged.

COMPOSITIONS AND METHODS FOR MODULAR CONTROL OF BIOORTHOGONAL LIGATION

The present invention provides a compound having the structure: Formula (I) wherein R1 is H or a protecting group; R2 and R3 are each independently H, halo, C1-C6 alkyl, C2-C6 al

OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF

The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.

1,3-DISUBSTITUTED AZETIDINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES

Compounds of formula Ia or Ib in free or salt form, wherein Ar, X1, X2, m, R1, Q, Y, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by CCR-3, for example an inflammatory or allergic cond