ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride

Base Information

Chemical Name:ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride
CAS No.:124769-87-5
Molecular Formula:C₁₈H₂₃N₃O₄*ClH
Molecular Weight:381.859
Hs Code.:

Synonyms:ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride

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Chemical Property of ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride

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Technology Process of ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride

There total 5 articles about ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 67-56-1
methanol

: 124769-86-4
ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate

: 124769-87-5
ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride

Guidance literature:: for 3h; Heating;
DOI:10.1248/cpb.37.1780

Reference yield:

: 53554-29-3
ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate

: 124769-87-5
ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / 2 h / 130 °C

2: 54 percent / POCl₃, N,N-diethylaniline / acetonitrile / 3 h / Heating

3: 68 percent / 3 h / Heating

With N,N-diethylaniline; trichlorophosphate; In acetonitrile;
DOI:10.1248/cpb.37.1780

Reference yield:

: 56245-02-4
1-isobutoxy-2-nitrobenzene

: 124769-87-5
ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 10percent Pd/C / methanol

2: 74 percent / 2 h / 130 °C

3: 54 percent / POCl₃, N,N-diethylaniline / acetonitrile / 3 h / Heating

4: 68 percent / 3 h / Heating

With hydrogen; N,N-diethylaniline; trichlorophosphate; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1248/cpb.37.1780