3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Base Information

Chemical Name:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid
CAS No.:1445786-82-2
Molecular Formula:C₂₉H₂₉N₅O₅
Molecular Weight:527.58
Hs Code.:

Synonyms:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

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Chemical Property of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

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Technology Process of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

There total 10 articles about 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1445789-90-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate

: 1445786-82-2
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 25 ℃; for 20h;

Reference yield:

: 6307-87-5
methyl 3-bromo-5-nitrobenzoate

: 1445786-82-2
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 12 h / 50 °C

3: acetic acid / 3 h / 50 °C

4: lithium hydroxide / tetrahydrofuran / 20 h / 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1445790-44-2
methyl 3-(cyclopent-1-en-1-yl)-5-nitrobenzoate

: 1445786-82-2
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 12 h / 50 °C

2: acetic acid / 3 h / 50 °C

3: lithium hydroxide / tetrahydrofuran / 20 h / 25 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol;