methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate

Base Information

Chemical Name:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate
CAS No.:1445789-90-1
Molecular Formula:C₃₀H₃₁N₅O₅
Molecular Weight:541.607
Hs Code.:

Synonyms:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate

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Chemical Property of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate

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Technology Process of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate

There total 9 articles about methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.9%

: 1445790-46-4
methyl 3-amino-5-cyclopentylbenzoate

: 1445789-00-3
4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinoline-3-carboxamide

: 1445789-90-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: With acetic acid; at 50 ℃; for 3h;

Reference yield:

: 6307-87-5
methyl 3-bromo-5-nitrobenzoate

: 1445789-90-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 12 h / 50 °C

3: acetic acid / 3 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1445790-44-2
methyl 3-(cyclopent-1-en-1-yl)-5-nitrobenzoate

: 1445789-90-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-methylquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 12 h / 50 °C

2: acetic acid / 3 h / 50 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol;