(+/-)-(3S,4R)-5,5-dibenzyl-1-hydroxy-3,4-dimethyl-3-phenylthiopyrrolidin-2-one

Base Information

Chemical Name:(+/-)-(3S,4R)-5,5-dibenzyl-1-hydroxy-3,4-dimethyl-3-phenylthiopyrrolidin-2-one
CAS No.:114090-90-3
Molecular Formula:C₂₆H₂₇NO₂S
Molecular Weight:417.572
Hs Code.:

Synonyms:(+/-)-(3S,4R)-5,5-dibenzyl-1-hydroxy-3,4-dimethyl-3-phenylthiopyrrolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-(3S,4R)-5,5-dibenzyl-1-hydroxy-3,4-dimethyl-3-phenylthiopyrrolidin-2-one

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Technology Process of (+/-)-(3S,4R)-5,5-dibenzyl-1-hydroxy-3,4-dimethyl-3-phenylthiopyrrolidin-2-one

There total 1 articles about (+/-)-(3S,4R)-5,5-dibenzyl-1-hydroxy-3,4-dimethyl-3-phenylthiopyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

: 114090-88-9,114090-89-0
5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one

: 74-88-4
methyl iodide

: 114090-90-3
(+/-)-(3S,4R)-5,5-dibenzyl-1-hydroxy-3,4-dimethyl-3-phenylthiopyrrolidin-2-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; 1.) -78 deg C, then 4 deg C, 3.5 h; 2.) 4 deg C, 15 min;
DOI:10.1039/P19870002027

Reference yield: 90.8%

: 114090-90-3
(+/-)-(3S,4R)-5,5-dibenzyl-1-hydroxy-3,4-dimethyl-3-phenylthiopyrrolidin-2-one

: 114090-91-4
5,5-dibenzyl-1-hydroxy-3,4-dimethylpyrrol-2(5H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 17h;
DOI:10.1039/P19870002027

Reference yield:

: 114090-90-3
(+/-)-(3S,4R)-5,5-dibenzyl-1-hydroxy-3,4-dimethyl-3-phenylthiopyrrolidin-2-one

: 91956-38-6
2-benzyl-3,4-dimethyl-pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: 90.8 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 17 h / 0 °C

2: 93.7 percent / Zn powder / acetic acid / 3.5 h / Ambient temperature

3: 96 percent / Lawesson's reagent / benzene / 0.5 h / Heating

4: Raney nickel

With Lawessons reagent; nickel; 3-chloro-benzenecarboperoxoic acid; zinc; In dichloromethane; acetic acid; benzene;
DOI:10.1039/P19870002027