trans-5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one

Base Information

Chemical Name:trans-5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one
CAS No.:114090-88-9
Molecular Formula:C₂₅H₂₅NO₂S
Molecular Weight:403.545
Hs Code.:

Synonyms:

Suppliers and Price of trans-5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one

There total 12 articles about trans-5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6125-24-2
2-Phenylnitroethane

: 114090-88-9,114090-89-0
cis-5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: MeNH₂*HCl, AcOK, trimethyl orthoformate / methanol / 16 h / Heating

2: NaBH₄ / dimethylsulfoxide / 1 h / 20 °C

3: 63.4 percent / tetrabutylammonium chloride, KF*2H₂O / dimethylformamide / 50 h / 60 °C

4: 82.1 percent / Zn powder / acetic acid / 1.) r.t., 20 min; 2.) 100 deg C, 3 h

5: 1.) lithium di-isopropylamide / tetrahydrofuran / 1.) -78 deg C, then r.t., 1 h; 2.) 0 deg C, then r.t., 15 min

With potassium fluoride; sodium tetrahydroborate; tetrabutyl-ammonium chloride; methylamine hydrochloride; potassium acetate; zinc; lithium diisopropyl amide; trimethyl orthoformate; In tetrahydrofuran; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19870002027

Reference yield:

: 6125-24-2
2-Phenylnitroethane

: 114090-88-9,114090-89-0
trans-5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: MeNH₂*HCl, AcOK, trimethyl orthoformate / methanol / 16 h / Heating

2: NaBH₄ / dimethylsulfoxide / 1 h / 20 °C

3: 63.4 percent / tetrabutylammonium chloride, KF*2H₂O / dimethylformamide / 50 h / 60 °C

4: 82.1 percent / Zn powder / acetic acid / 1.) r.t., 20 min; 2.) 100 deg C, 3 h

5: 1.) lithium di-isopropylamide / tetrahydrofuran / 1.) -78 deg C, then r.t., 1 h; 2.) 0 deg C, then r.t., 15 min

With potassium fluoride; sodium tetrahydroborate; tetrabutyl-ammonium chloride; methylamine hydrochloride; potassium acetate; zinc; lithium diisopropyl amide; trimethyl orthoformate; In tetrahydrofuran; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19870002027

Reference yield:

: 58497-32-8
(2-nitroprop-1-ene-1,3-diyl)dibenzene

: 114090-88-9,114090-89-0
cis-5,5-dibenzyl-1-hydroxy-4-methyl-3-phenylthiopyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / dimethylsulfoxide / 1 h / 20 °C

2: 63.4 percent / tetrabutylammonium chloride, KF*2H₂O / dimethylformamide / 50 h / 60 °C

3: 82.1 percent / Zn powder / acetic acid / 1.) r.t., 20 min; 2.) 100 deg C, 3 h

4: 1.) lithium di-isopropylamide / tetrahydrofuran / 1.) -78 deg C, then r.t., 1 h; 2.) 0 deg C, then r.t., 15 min

With potassium fluoride; sodium tetrahydroborate; tetrabutyl-ammonium chloride; zinc; lithium diisopropyl amide; In tetrahydrofuran; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19870002027