(4Z/E)-4-methoxyimino-1-[(2’-methyl-1,1’-biphenyl-4-yl)carbonyl]-L-proline

Base Information

Chemical Name:(4Z/E)-4-methoxyimino-1-[(2’-methyl-1,1’-biphenyl-4-yl)carbonyl]-L-proline
CAS No.:461418-05-3
Molecular Formula:C₂₀H₂₀N₂O₄
Molecular Weight:352.39
Hs Code.:

Synonyms:(4Z/E)-4-methoxyimino-1-[(2’-methyl-1,1’-biphenyl-4-yl)carbonyl]-L-proline

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Chemical Property of (4Z/E)-4-methoxyimino-1-[(2’-methyl-1,1’-biphenyl-4-yl)carbonyl]-L-proline

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Technology Process of (4Z/E)-4-methoxyimino-1-[(2’-methyl-1,1’-biphenyl-4-yl)carbonyl]-L-proline

There total 10 articles about (4Z/E)-4-methoxyimino-1-[(2’-methyl-1,1’-biphenyl-4-yl)carbonyl]-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

: 863976-38-9
1-(2’-methyl-1,1’-biphenyl-4-yl)carbonyl-4-oxo-L-proline

: 593-56-6
N-methoxylamine hydrochloride

: 461418-05-3
(4Z/E)-4-methoxyimino-1-[(2’-methyl-1,1’-biphenyl-4-yl)carbonyl]-L-proline

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; for 16 - 20h;

Reference yield: 91.0%

: 461418-01-9
(4Z/E,2S)-methyl-1[(2’-methyl-1,1‘-biphenyl-4-yl)-carbonyl]-4-methoxyimino pyrrolidine-2-carboxylate

: 461418-05-3
(4Z/E)-4-methoxyimino-1-[(2’-methyl-1,1’-biphenyl-4-yl)carbonyl]-L-proline

Guidance literature:: (4Z/E,2S)-methyl-1[(2’-methyl-1,1‘-biphenyl-4-yl)-carbonyl]-4-methoxyimino pyrrolidine-2-carboxylate; With sodium hydroxide; water; In 1,4-dioxane; at 20 ℃; for 4h;

With hydrogenchloride; In water;

Reference yield:

: 16419-60-6
2-Methylphenylboronic acid

: 461418-05-3
(4Z/E)-4-methoxyimino-1-[(2’-methyl-1,1’-biphenyl-4-yl)carbonyl]-L-proline

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; methanol / 71 - 78 °C / Inert atmosphere

2: thionyl chloride / toluene / 75 - 80 °C

3: potassium carbonate / water; toluene; tetrahydrofuran / 0 - 25 °C

4: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 15 - 25 °C

5: triethylamine / dichloromethane / 10 - 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;