3-benzyloxy-17-cyclopropylmethyl-14-(2',3'-dihydroxypropyloxy)-6-dimethoxy-4,5α-epoxymorphinan

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Chemical Name:3-benzyloxy-17-cyclopropylmethyl-14-(2',3'-dihydroxypropyloxy)-6-dimethoxy-4,5α-epoxymorphinan
CAS No.:1192542-77-0
Molecular Formula:C₃₂H₄₁NO₇
Molecular Weight:551.68
Hs Code.:

Synonyms:3-benzyloxy-17-cyclopropylmethyl-14-(2',3'-dihydroxypropyloxy)-6-dimethoxy-4,5α-epoxymorphinan

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Chemical Property of 3-benzyloxy-17-cyclopropylmethyl-14-(2',3'-dihydroxypropyloxy)-6-dimethoxy-4,5α-epoxymorphinan

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Technology Process of 3-benzyloxy-17-cyclopropylmethyl-14-(2',3'-dihydroxypropyloxy)-6-dimethoxy-4,5α-epoxymorphinan

There total 4 articles about 3-benzyloxy-17-cyclopropylmethyl-14-(2',3'-dihydroxypropyloxy)-6-dimethoxy-4,5α-epoxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1032280-40-2
14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan

: 1192542-77-0
3-benzyloxy-17-cyclopropylmethyl-14-(2',3'-dihydroxypropyloxy)-6-dimethoxy-4,5α-epoxymorphinan

Guidance literature:: 14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan; osmium(VIII) oxide; In water; acetone; tert-butyl alcohol; at 0 ℃; for 0.166667h;

With 4-methylmorpholine N-oxide; In water; acetone; tert-butyl alcohol; at 0 - 20 ℃; for 4.5h;

Reference yield:

: 1032282-06-6
17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-6,6-dimethoxymorphinan

: 1192542-77-0
3-benzyloxy-17-cyclopropylmethyl-14-(2',3'-dihydroxypropyloxy)-6-dimethoxy-4,5α-epoxymorphinan

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / Inert atmosphere

2.2: 20 °C

3.1: osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 0.17 h / 0 °C

3.2: 4.5 h / 0 - 20 °C

With sodium hydride; potassium carbonate; osmium(VIII) oxide; In water; N,N-dimethyl-formamide; acetone; mineral oil; tert-butyl alcohol;

Reference yield:

: 1032280-22-0
17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

: 1192542-77-0
3-benzyloxy-17-cyclopropylmethyl-14-(2',3'-dihydroxypropyloxy)-6-dimethoxy-4,5α-epoxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / Inert atmosphere

1.2: 20 °C

2.1: osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 0.17 h / 0 °C

2.2: 4.5 h / 0 - 20 °C

With sodium hydride; osmium(VIII) oxide; In water; N,N-dimethyl-formamide; acetone; mineral oil; tert-butyl alcohol;