17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

Base Information

Chemical Name:17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan
CAS No.:1032280-22-0
Molecular Formula:C₂₉H₃₅NO₅
Molecular Weight:477.601
Hs Code.:

Synonyms:17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

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Chemical Property of 17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

Chemical Property:

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Technology Process of 17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

There total 3 articles about 17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 153567-11-4
2,2,2-trichloroethyl (4'R,7a'R,12b'S)-9'-(benzyloxy)-1',2',4',6'-tetrahydro-3'H,7a'Hspiro[[1,3]dioxolane-2,7'-[4,12]methanobenzofuro[3,2-e]isoquinoline]-3'-carboxylate

: 149-73-5
trimethyl orthoformate

: 1032280-59-3
17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

: 1032280-22-0
17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

Guidance literature:: 2,2,2-trichloroethyl (4'R,7a'R,12b'S)-9'-(benzyloxy)-1',2',4',6'-tetrahydro-3'H,7a'Hspiro[[1,3]dioxolane-2,7'-[4,12]methanobenzofuro[3,2-e]isoquinoline]-3'-carboxylate; trimethyl orthoformate; With sulfuric acid;

With ammonia; In water; Product distribution / selectivity;

Reference yield:

: 1032282-06-6
17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-6,6-dimethoxymorphinan

: 100-39-0
benzyl bromide

: 1032280-22-0
17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 20h;

Reference yield:

: 16676-29-2
naltrexone Hydrochloride

: 1032280-22-0
17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol; diethyl ether / 3 h / 20 °C

1.2: pH > 7

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Inert atmosphere

With hydrogenchloride; potassium carbonate; In methanol; diethyl ether; N,N-dimethyl-formamide;