14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan

Base Information

Chemical Name:14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan
CAS No.:1032280-40-2
Molecular Formula:C₃₂H₃₉NO₅
Molecular Weight:517.665
Hs Code.:

Synonyms:14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan

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Chemical Property of 14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan

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Technology Process of 14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan

There total 3 articles about 14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1032280-22-0
17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan

: 106-95-6
allyl bromide

: 1032280-40-2
14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan

Guidance literature:: 17-cyclopropylmethyl-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,6-dimethoxymorphinan; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333 - 1h;

allyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Product distribution / selectivity;

Reference yield:

: 1032282-06-6
17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-6,6-dimethoxymorphinan

: 1032280-40-2
14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / Inert atmosphere

2.2: 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 16676-29-2
naltrexone Hydrochloride

: 1032280-40-2
14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-6,6-dimethoxymorphinan

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / methanol; diethyl ether / 3 h / 20 °C

1.2: pH > 7

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / Inert atmosphere

3.2: 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; In methanol; diethyl ether; N,N-dimethyl-formamide; mineral oil;