diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(phthalimidooxy)acetate

Base Information

• Chemical Name: diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(phthalimidooxy)acetate
• CAS No.: 120708-97-6
• Molecular Formula: C₃₂H₂₅NO₇
• Molecular Weight: 535.553
• Mol file: 120708-97-6.mol

Synonyms:diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(phthalimidooxy)acetate

Chemical Property of diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(phthalimidooxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(phthalimidooxy)acetate

There total 7 articles about diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(phthalimidooxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-hydroxyphthalimide (524-38-9) + diphenylmethyl (R)-2-(3,4-isopropylidenedioxyphenyl)-2-hydroxyacetate (120633-49-0) → diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(phthalimidooxy)acetate (120708-97-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In ethyl acetate; at -20 ℃; for 1h;

DOI:10.1246/bcsj.64.175

Reference yield:

2,2-dimethyl-1,3-benzodioxole (14005-14-2) → diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(phthalimidooxy)acetate (120708-97-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 86 percent / AlCl₃ / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂O / 22 h / 30 °C / sucrose, baker's yeast

3: 79 percent / 48percent NaOH / methanol / 1.5 h / 30 °C

4: 92 percent / ethyl acetate; CH₂Cl₂ / 1 h / T < 35 deg C

5: 86 percent / PPh₃, diethyl azodicarboxylate / ethyl acetate / 1 h / -20 °C

With sodium hydroxide; aluminium trichloride; triphenylphosphine; diethylazodicarboxylate; In methanol; dichloromethane; water; ethyl acetate;

DOI:10.1246/bcsj.64.175

Reference yield:

(R)-2-(3,4-O-isopropylidenedioxyphenyl)-2-hydroxyacetic acid (120708-96-5) → diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(phthalimidooxy)acetate (120708-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / ethyl acetate; CH₂Cl₂ / 1 h / T < 35 deg C

2: 86 percent / PPh₃, diethyl azodicarboxylate / ethyl acetate / 1 h / -20 °C

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; ethyl acetate;

DOI:10.1246/bcsj.64.175

upstream raw materials:

N-hydroxyphthalimide

diphenylmethyl (R)-2-(3,4-isopropylidenedioxyphenyl)-2-hydroxyacetate

2,2-dimethyl-1,3-benzodioxole

(R)-2-(3,4-O-isopropylidenedioxyphenyl)-2-hydroxyacetic acid

Downstream raw materials:

diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-(aminooxy)acetate

diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-<<(+)-10-camphorsulfonyl>aminooxy>acetate

diphenylmethyl (S)-2-(3,4-isopropylidenedioxyphenyl)-2-<<(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionyl>aminooxy>acetate