14005-14-2

Usage

Uses

Used in Fragrance Industry:
2,2-Dimethyl-1,3-benzodioxole is used as a fragrance ingredient for its appealing scent, contributing to the creation of perfumes and personal care products.
Used in Flavor and Fragrance Manufacturing:
It serves as a key component in the development of flavors and fragrances, enhancing the sensory experience of various consumer products.
Used in Pharmaceutical Production:
2,2-Dimethyl-1,3-benzodioxole is utilized in the production of pharmaceuticals, capitalizing on its chemical properties to contribute to the formulation of medicinal compounds.
Used in Antimicrobial Applications:
Leveraging its antimicrobial properties, 2,2-Dimethyl-1,3-benzodioxole is employed in applications where the control of microbial growth is necessary, offering a natural alternative for disinfection and preservation.
Used in Chemical Compounds Production:
It is also a component in the synthesis of other chemical compounds, broadening its industrial applications beyond the realms of fragrance and pharmaceuticals.

InChI:InChI=1/C9H10O2/c1-9(2)10-7-5-3-4-6-8(7)11-9/h3-6H,1-2H3

Upstream product

• 4442-72-2 (2-methyl-benzo[1,3]dioxol-2-yl)-acetic acid 
• 120-80-9 benzene-1,2-diol 
• 67-64-1 acetone 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 73790-19-9 5-bromo-2,2-dimethyl-1,3-benzodioxole 
• 114414-23-2 5,6-dibromo-2,2-dimethyl-benzo[1,3]dioxole 
• 6860-95-3 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)ethanone 
• 54186-68-4 2,2-dimethyl-5-nitro-1,3-benzodioxole 
• 87275-24-9 2-(isopropenoxy)-1-acetoxybenzene 
• 87275-22-7 2-(α-hydroxyisopropoxy)-1-acetoxybenzene 
• 87275-23-8 2-(α-bromoisopropoxy)-1-acetoxybenzene 
• 630-13-7 2,2-diiodopropane 
• 635-67-6 dimethyl phthalate 
• 72712-21-1 3,4-diacetoxyacetophenone 
• 120-80-9 benzene-1,2-diol 
• 4812-20-8 2-Isopropoxyphenol 
• 875325-89-6 4,5-diodo-1,2-bis[2-[2-(2-hydroxyethoxy)ethoxy]-ethoxy]benzene 
• 875325-90-9 4,5-diiodo-1,2-bis[2-[2-[2-[[(4-tosyl)sulfonyl]oxy]-ethoxy]ethoxy]ethoxy]benzene 

Relevant academic research and scientific papers

Synthesis, Antiviral Activity, and Structure–Activity Relationship of 1,3-Benzodioxolyl Pyrrole-Based Entry Inhibitors Targeting the Phe43 Cavity in HIV-1 gp120

The pathway by which HIV-1 enters host cells is a prime target for novel drug discovery because of its critical role in the life cycle of HIV-1. The HIV-1 envelope glycoprotein gp120 plays an important role in initiating virus entry by targeting the primary cell receptor CD4. We explored the substitution of bulky molecular groups in region I in the NBD class of entry inhibitors. Previous attempts at bulky substituents in that region abolished antiviral activity, even though the binding site is hydrophobic. We synthesized a series of entry inhibitors containing the 1,3-benzodioxolyl moiety or its bioisostere, 2,1,3-benzothiadiazole. The introduction of the bulkier groups was well tolerated, and despite only minor improvements in antiviral activity, the selectivity index of these compounds improved significantly.

Montmorillonite clay catalysis. Part 14. A facile synthesis of 2-substituted and 2,2-disubstituted 1,3-benzodioxoles

A series of 2-substituted and 2,2-disubstituted 1,3-benzodioxoles have been synthesised by reaction of catechol and pyrogallol with corresponding aldehydes and ketones catalysed by montmorillonite KSF or K-10. The reactions are completed within 2.7-24 h to give satisfactory yields. Ketones give better yields than aldehydes, although highly sterically hindered ketones and diaryl ketones fail to react at all.

Synthesis of Catecholate Ligands with Phosphonate Anchoring Groups

New catecholate ligands containing protected phosphonate anchoring groups in the 4-position of the catecholate ring were synthesized. The catechol 4-diethoxyphosphorylbenzene-1,2-diol, (Etphoscat)H2, was prepared in three steps from pyrocatechol; whereas, the catechol 4-(diethoxyphosphorylmethyl)benzene-1,2-diol, (EtBnphoscat)H2, containing a methylene spacer between the catecholate ring and phosphonate anchor, was prepared from protocatechuic acid in six linear steps. Both catechol derivatives were further elaborated to their trimethylsilyl-protected counterparts to facilitate their binding to nanocrystalline metal oxides. Electronic spectroscopy and cyclic voltammetry were used to probe the electronic properties of the phosphonate-functionalized catecholates in charge-transfer complexes of the general formula (catecholate)Pd(pdi) (pdi = N,N′-bis(mesityl)phenanthrene-9,10-diimine). These studies show that attachment of the phosphonate anchor directly to the 4-position of the (Etphoscat)2- ligand significantly perturbs the donor ability of the catecholate ligand; however, incorporation of a single methylene spacer group in (EtBnphoscat)2- helps to isolate catecholate from the electron-withdrawing phosphonate group.

Synthesis of 4,5-dihydroxyphthalonitrile

4,5-Dihydroxyphthalonitrile was synthesized from pyrocatechol in a simple way. The compound obtained is a convenient starting reagent for the preparation of 4,5-dialkoxyphthalonitriles.

Synthesis and biological activity of 2-carbomethoxy-3-catechol-8- azabicyclo[3.2.1]octanes

Cocaine inhibits the dopamine transporter and the consequent elevation of dopamine is thought to contribute to the addictive properties of cocaine. Tropane analogues of cocaine, targeted to the dopamine transporter (DAT), are a significant focus of drug d

Quinoxaline compound, preparation method and application of quinoxaline compound in medicine

The invention provides a quinoxaline compound, a preparation method and application of the quinoxaline compound in medicine, and particularly relates to a quinoxaline compound with PAR4 antagonistic activity, a preparation method of the quinoxaline compound, a pharmaceutical composition containing the quinoxaline compound and application of the quinoxaline compound. Specifically, the invention provides a compound shown as a general formula I and/or II or a tautomer or pharmaceutically acceptable salt thereof, a preparation method of the compound, and application of the compound or the tautomer or the pharmaceutically acceptable salt in medicines for preventing and/or treating thromboembolic diseases.

Templated Chromophore Assembly on Peptide Scaffolds: A Structural Evolution

The use of a template that bears pre-programmed receptor sites for selectively accommodating chromophores at given positions is an attractive approach for engineering artificial-light-harvesting systems. Indulging this line of thought, this work tackles the creation of tailored antenna architectures with yellow, red and blue chromophores, exploiting three dynamic covalent reactions simultaneously, namely disulfide exchange, acyl hydrazone, and boronic ester formations. The effect of various structural modifications, such as the chromophores as well as their spatial organization (distance, orientation, order) on the energy transfer within the antennas was studied by means of steady-state UV/Vis absorption and fluorescence spectroscopies. This systematic study allowed for a significant improvement of the energy-transfer efficiencies to a noticeable 22 and 15 % for the yellow and red donors, respectively, across the chromophores to the blue acceptor. Metadynamics simulations suggested that the conformational properties of the antennas are driven by intramolecular chromophoric stacking interactions that, upon forcing the α-helix to fold on itself, annul any effects deriving from the programming of the spatial arrangement of the receptor sides in the peptide backbone.

N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES

The present invention provides e.g. N-{[2-(piperidin-1-yl)phenyl] (phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating e.g. autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases or cholestatic diseases, such as e.g. arthitis and asthma.

Class of large ring heterocyclic compound restraining HCV and manufacturing and uses thereof

The invention relates to a class of compounds that inhibit HCV. The compounds are represented by Formula A. The invention also relates to preparation and pharmaceutical use of the compounds.

Synthesis of a functionalized benzofuran as a synthon for salvianolic acid C analogues as potential LDL Antioxidants

A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may