1-[3-(p-nitrophenyl)-2H-chromen-2-ylidene]-4-phenylsemicarbazide

Base Information

• Chemical Name: 1-[3-(p-nitrophenyl)-2H-chromen-2-ylidene]-4-phenylsemicarbazide
• CAS No.: 1277101-39-9
• Molecular Formula: C₂₂H₁₆N₄O₄
• Molecular Weight: 400.393
• Mol file: 1277101-39-9.mol

Synonyms:1-[3-(p-nitrophenyl)-2H-chromen-2-ylidene]-4-phenylsemicarbazide

Chemical Property of 1-[3-(p-nitrophenyl)-2H-chromen-2-ylidene]-4-phenylsemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-(p-nitrophenyl)-2H-chromen-2-ylidene]-4-phenylsemicarbazide

There total 2 articles about 1-[3-(p-nitrophenyl)-2H-chromen-2-ylidene]-4-phenylsemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Nitrophenylacetonitrile (555-21-5,34512-13-5,174848-08-9) → 1-[3-(p-nitrophenyl)-2H-chromen-2-ylidene]-4-phenylsemicarbazide (1277101-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Amberlite IRA 900 resin / toluene / 3 h / 85 °C / Inert atmosphere

1.2: 8 h / Inert atmosphere; Reflux

2.1: acetic acid / chloroform / 2 h / 20 °C

With acetic acid; In chloroform; toluene; 2.1: Schmidt reaction;

DOI:10.1080/00397911003710562

Reference yield:

salicylaldehyde (90-02-8) → 1-[3-(p-nitrophenyl)-2H-chromen-2-ylidene]-4-phenylsemicarbazide (1277101-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Amberlite IRA 900 resin / toluene / 3 h / 85 °C / Inert atmosphere

1.2: 8 h / Inert atmosphere; Reflux

2.1: acetic acid / chloroform / 2 h / 20 °C

With acetic acid; In chloroform; toluene; 2.1: Schmidt reaction;

DOI:10.1080/00397911003710562

Reference yield: 88.0%

oxalyl dichloride (79-37-8) + 1-[3-(p-nitrophenyl)-2H-chromen-2-ylidene]-4-phenylsemicarbazide (1277101-39-9) → C24H14N4O6 (1277101-44-6)

Guidance literature:

With pyridine; In 1,2-dichloro-ethane; at 20 - 60 ℃; for 12.5h;

DOI:10.1080/00397911003710562

upstream raw materials:

4-Nitrophenylacetonitrile

salicylaldehyde

Downstream raw materials:

C₂₄H₁₄N₄O₆