2',3'-O,O-bis(t-butyldimethylsilyl)-5'-O-(N-salicylsulfamoyl)adenosine

Base Information

Chemical Name:2',3'-O,O-bis(t-butyldimethylsilyl)-5'-O-(N-salicylsulfamoyl)adenosine
CAS No.:863238-54-4
Molecular Formula:C₂₉H₄₆N₆O₈SSi₂
Molecular Weight:694.957
Hs Code.:

Synonyms:2',3'-O,O-bis(t-butyldimethylsilyl)-5'-O-(N-salicylsulfamoyl)adenosine

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Chemical Property of 2',3'-O,O-bis(t-butyldimethylsilyl)-5'-O-(N-salicylsulfamoyl)adenosine

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Technology Process of 2',3'-O,O-bis(t-butyldimethylsilyl)-5'-O-(N-salicylsulfamoyl)adenosine

There total 6 articles about 2',3'-O,O-bis(t-butyldimethylsilyl)-5'-O-(N-salicylsulfamoyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 863238-53-3
2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(sulfamoyl)adenosine

: 347370-91-6
(1H-benzo[d][1,2,3]triazol-1-yl)(2-hydroxyphenyl)methanone

: 863238-54-4
2',3'-O,O-bis(t-butyldimethylsilyl)-5'-O-(N-salicylsulfamoyl)adenosine

Guidance literature:: With triethylamine; In 1,4-dioxane; acetonitrile; at 60 ℃; Inert atmosphere;
DOI:10.1128/AAC.00918-13

Reference yield: 80.0%

: 863238-53-3
2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(sulfamoyl)adenosine

: 863238-54-4
2',3'-O,O-bis(t-butyldimethylsilyl)-5'-O-(N-salicylsulfamoyl)adenosine

Guidance literature:: salicylic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 60 ℃; for 2h;

2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(sulfamoyl)adenosine; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 60 ℃; for 0.5h;

Reference yield:

: 58-61-7
adenosine

: 863238-54-4
2',3'-O,O-bis(t-butyldimethylsilyl)-5'-O-(N-salicylsulfamoyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; 1,2-dimethoxyethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 16.33 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / acetonitrile; 1,4-dioxane / 60 °C / Inert atmosphere

With 1H-imidazole; sodium hydride; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1128/AAC.00918-13