2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE

Base Information

• Chemical Name: 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE
• CAS No.: 26974-09-4
• Molecular Formula: C11H8F3N3
• Molecular Weight: 239.2
• Hs Code.: 29335990
• Mol file: 26974-09-4.mol

Synonyms:Pyrimidine,2-amino-4-phenyl-6-(trifluoromethyl)- (8CI);2-Amino-4-phenyl-6-(trifluoromethyl)pyrimidine;4-Phenyl-6-(trifluoromethyl)-2-pyrimidinylamine;

Chemical Property of 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Melting Point: 131-133 °C
• Refractive Index: 1.524
• Boiling Point: 397.5 °C at 760 mmHg
• Flash Point: 194.2 °C
• PSA: 51.80000
• Density: 1.351 g/cm³
• LogP: 3.32580

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-phenyl-6-(trifluoromethyl)pyrimidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE

There total 13 articles about 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-trifluoromethyl-6-phenyl-2-acetylaminopyrimidine (1020540-98-0) → 2-amino-4-phenyl-6-(trifluoromethyl)pyrimidine (26974-09-4)

Guidance literature:

With ferric nitrate; In methanol; at 40 ℃; for 24h;

DOI:10.1002/jhet.5570450228

Reference yield: 89.0%

1-Phenyl-4,4,4-trifluorobutane-1,3-dione (326-06-7) → 2-amino-4-phenyl-6-(trifluoromethyl)pyrimidine (26974-09-4)

Guidance literature:

With sodium methylate; In methanol; for 6h; Reflux;

DOI:10.3390/molecules21070828

Reference yield: 85.0%

diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) + 1,1,1,2,2-pentafluoro-4-iodo-4-phenyl-3-butene (172032-06-3) → 2-amino-4-phenyl-6-(trifluoromethyl)pyrimidine (26974-09-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 40 ℃; for 36h;

DOI:10.1055/s-1997-1376

upstream raw materials:

1-Phenyl-4,4,4-trifluorobutane-1,3-dione

guanidinium sulfate

diguanidine carbonate

1,1,1,2,2-pentafluoro-4-iodo-4-phenyl-3-butene

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