(S)-2-(1-(tert-butoxycarbonyl)-3-(3,4-dichlorophenyl)piperidin-3-yl)acetic acid

Base Information

• Chemical Name: (S)-2-(1-(tert-butoxycarbonyl)-3-(3,4-dichlorophenyl)piperidin-3-yl)acetic acid
• CAS No.: 1231957-84-8
• Molecular Formula: C₁₈H₂₃Cl₂NO₄
• Molecular Weight: 388.291

Synonyms:(S)-2-(1-(tert-butoxycarbonyl)-3-(3,4-dichlorophenyl)piperidin-3-yl)acetic acid

Chemical Property of (S)-2-(1-(tert-butoxycarbonyl)-3-(3,4-dichlorophenyl)piperidin-3-yl)acetic acid

Chemical Property:

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Technology Process of (S)-2-(1-(tert-butoxycarbonyl)-3-(3,4-dichlorophenyl)piperidin-3-yl)acetic acid

There total 1 articles about (S)-2-(1-(tert-butoxycarbonyl)-3-(3,4-dichlorophenyl)piperidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-hydroxyethyl)piperidine-1-carboxylate (1231957-78-0) → (S)-2-(1-(tert-butoxycarbonyl)-3-(3,4-dichlorophenyl)piperidin-3-yl)acetic acid (1231957-84-8)

Guidance literature:

(S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-hydroxyethyl)piperidine-1-carboxylate; With dipyridinium dichromate; In N,N-dimethyl-formamide; at 5 - 25 ℃; Inert atmosphere;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 0 ℃;

Reference yield: 100.0%

methanol (67-56-1) + (S)-2-(1-(tert-butoxycarbonyl)-3-(3,4-dichlorophenyl)piperidin-3-yl)acetic acid (1231957-84-8) → (S)-methyl 2-(3-(3,4-dichlorophenyl)piperidin-3-yl)acetate (1231957-85-9)

Guidance literature:

With chloro-trimethyl-silane; at 25 ℃; for 24h; Inert atmosphere;

Reference yield:

azetidine (503-29-7) + (S)-2-(1-(tert-butoxycarbonyl)-3-(3,4-dichlorophenyl)piperidin-3-yl)acetic acid (1231957-84-8) → (S)-tert-butyl 3-(2-(azetidin-1-yl)-2-oxoethyl)-3-(3,4-dichlorophenyl)piperidine-1-carboxylate (1231957-98-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 25 ℃; Inert atmosphere;

upstream raw materials:

(S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-hydroxyethyl)piperidine-1-carboxylate

Downstream raw materials:

(S)-tert-butyl 3-(2-(azetidin-1-yl)-2-oxoethyl)-3-(3,4-dichlorophenyl)piperidine-1-carboxylate

(S)-methyl 2-(3-(3,4-dichlorophenyl)piperidin-3-yl)acetate

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