Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester
CAS No.:115446-62-3
Molecular Formula:C₃₆H₄₅NO₅S
Molecular Weight:603.823
Hs Code.:

Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Synonyms:Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Suppliers and Price of Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

There total 9 articles about Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-({[1-(2-ethoxy-phenyl)-meth-(E)-ylidene]-amino}-methyl)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

: 115446-62-3
Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃; for 6h; Yield given;
DOI:10.1016/S0040-4020(01)81681-1

Reference yield:

: 112897-80-0
3-methoxy-16α-(p-tolylsulfonyloxymethyl)estra-1,3,5(10)-trien-17β-ol

: 115446-62-3
Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / NaN₃ / dimethylformamide / 6 h / 100 °C

2: 87 percent / pyridine / 6 h / 45 °C

3: 70 percent / N₂H₄*H₂O / Raney Ni / ethanol / 1.) room temperature,12 h, 2.) reflux,2 h

4: ethanol / 3 h / Heating

5: NaBH₄ / ethanol / 6 h / 0 °C

With pyridine; sodium tetrahydroborate; sodium azide; hydrazine hydrate; nickel; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)81681-1

Reference yield:

: 64336-08-9
16α-hydroxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

: 115446-62-3
Toluene-4-sulfonic acid (8R,9S,13S,14S,16S,17S)-16-[(2-ethoxy-benzylamino)-methyl]-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / pyridine / 6 h / 45 °C

2: NaN₃ / dimethylformamide / 12 h / 100 °C

3: 70 percent / N₂H₄*H₂O / Raney Ni / ethanol / 1.) room temperature,12 h, 2.) reflux,2 h

4: ethanol / 3 h / Heating

5: NaBH₄ / ethanol / 6 h / 0 °C

With pyridine; sodium tetrahydroborate; sodium azide; hydrazine hydrate; nickel; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)81681-1