2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile

Base Information

• Chemical Name: 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile
• CAS No.: 1086424-45-4
• Molecular Formula: C₂₀H₁₇ClFN₃O₂
• Molecular Weight: 385.825

Synonyms:2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile

Chemical Property of 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile

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Technology Process of 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile

There total 1 articles about 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3-difluorobenzonitrile (21524-39-0) + 8-chloro-5-hydroxy-spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one (460346-10-5) → 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile (1086424-45-4)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 20h;

Reference yield: 92.0%

2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile (1086424-45-4) → 2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluoro-N-hydroxybenzenecarboximidamide (1086425-06-0)

Guidance literature:

With hydroxylamine hydrochloride; potassium tert-butylate; In dimethyl sulfoxide; at 20 - 60 ℃; for 18.5h;

Reference yield: 82.0%

2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile (1086424-45-4) → 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzoic acid (1086424-19-2)

Guidance literature:

With sulfuric acid; water; In acetic acid; at 60 - 110 ℃; for 18h;

upstream raw materials:

2,3-difluorobenzonitrile

8-chloro-5-hydroxy-spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one

Downstream raw materials:

2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzoic acid

2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide

2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluoro-N-hydroxybenzenecarboximidamide

8'-chloro-5'-[2-(chloromethyl)-6-fluorophenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

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